(R)-(+)-4-甲氧基扁桃腈合成路线 （共 18 条）
反应条件
4 A molecular sieve; dimethylaluminum chloride; triphenyl-phosphine oxide; (S)-3,3'-bis[(diethylamino)methyl]-2,2'-dihydroxy-1,1'-binaphthalene in toluene T=-20°C; Strecker reaction; 20 h;
参考文献
Casas, Jesus; Najera, Carmen; Sansano, Jose M.; Saa, Jose M.
Organic Letters, 2002 , vol. 4, # 15 p. 2589 - 2592
反应条件
hydrogenchloride in water; ethyl acetate; toluene 1 h;
参考文献
Tetrahedron, , vol. 60, # 46 SPEC. ISS. p. 10487 - 10496
反应条件
almond meal; citrate buffer pH 5.5 in ethyl acetate T=4°C;
参考文献
Zandbergen; Van der Linden; Brussee; Van der Gen
Synthetic Communications, 1991 , vol. 21, # 12-13 p. 1387 - 1391
反应条件
chiral binaphthol lantanum alkoxide in dichloromethane T=-78°C; 10 h; other chiral binaphthol-modified lanthanum alkoxides; Product distribution;
参考文献
Journal of the Chemical Society - Perkin Transactions 1, , # 14 p. 2131 - 2132
反应条件
in di-isopropyl ether T=5°C; 91 h; almond meal oxynitrilase, 0.1 M tartrate buffer, pH 5.4;
参考文献
Kiljunen, Eero; Kanerva, Liisa T.
Tetrahedron Asymmetry, 1996 , vol. 7, # 4 p. 1105 - 1116
反应条件
Prunus mume (R)-hydroxynitrile lyase; citrate buffer in di-isopropyl ether pH=4.0; 20 h;
参考文献
Nanda, Samik; Kato, Yasuo; Asano, Yasuhisa
Tetrahedron, 2005 , vol. 61, # 46 p. 10908 - 10916
反应条件
1: 4-methoxy-benzaldehyde With (1R,2R)-cyclohexane-1,2-diylbis(2-azaethenyl-3-tert-butyl-2-hydroxybenzo-5-sulfonic acid) disodium salt; Manganese (II) acetate in methanol T=20°C; 0.5 h; 2: sodium cyanide in methanol T=20°C; 24 h; optical yield given as percent eeenantioselective reaction;
参考文献
Qu, Yanyang; Jing, Linhai; Wu, Zhiqing; Wu, Di; Zhou, Xiangge
Tetrahedron Asymmetry, 2010 , vol. 21, # 2 p. 187 - 190
反应条件
hydrogen fluoride in acetonitrile T=45°C; 5 h;
参考文献
Tetrahedron, , vol. 46, # 3 p. 979 - 986
反应条件
hydrogenchloride Ambient temperature; Title compound not separated from byproducts;
参考文献
Journal of the Chemical Society - Perkin Transactions 1, , # 9 p. 1293 - 1295
反应条件
1: molecular sieves 4 Angstroem; triphenylphosphine oxide; (S)-BINOLAM / dimethylaluminium chloride / toluene; hexane / 20 h / -20 °C 2: hydrochloric acid / H2O; ethyl acetate; toluene / 1 h View Scheme
参考文献
Tetrahedron, , vol. 60, # 46 SPEC. ISS. p. 10487 - 10496
