hydrogen; palladium in N,N-dimethyl-formamide 5 h;

sodium hydroxide in acetone 0.5 h;

1: 94 percent / Et3N, HOBt, EDC*HCl / dimethylformamide / 1.) 0 deg C, 2 h, 2.) RT, overnight 2: 92 percent / H2 / Pd / dimethylformamide / 5 h View Scheme