1,4-二噁螺[4.5]-8-癸胺合成路线 (共 16 条)
反应条件
ammonia; hydrogen; palladium 10 on activated carbon in methanol P=3000.3 Torr;
参考文献
MOTAC NEUROSCIENCE LIMITED
Patent: WO2009/56805 A1, 2009 ;
Location in patent: Page/Page column 62; 77 ;
WO 2009/056805 A1
反应条件
hydrogen; 10 Pd(OH)2/C in ethanol T=20°C;
参考文献
CHROMA THERAPEUTICS LTD.
Patent: WO2007/129040 A1, 2007 ;
Location in patent: Page/Page column 54-55 ;
WO 2007/129040 A1
反应条件
hydrogen; palladium dihydroxide in methanol 20 h;
参考文献
Carter, Percy H.; Cherney, Robert J.; Batt, Douglas G.; Duncia, John V.; Gardner, Daniel S.; Ko, Soo S.; Srivastava, Anurag S.; Yang, Michael G.
Patent: US2005/54627 A1, 2005 ;
Location in patent: Page/Page column 47 ;
US 20050054627 A1
反应条件
hydrogen; palladium 10 on activated carbon in methanol T=20°C;
参考文献
US2006/63791 A1, ;
Page/Page column 10 ;
反应条件
lithium aluminium tetrahydride in tetrahydrofuran 3 h; Reflux;
参考文献
Nirogi, Ramakrishna V. S.; Konda, Jagadishu Babu; Kambhampati, Ramasastry; Shinde, Anil; Bandyala, Thrinath Reddy; Gudla, Parandhama; Kandukuri, Kiran Kumar; Jayarajan, Pradeep; Kandikere, Vishwottam; Dubey, P. K.
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 22 p. 6980 - 6985,6
反应条件
lithium aluminium tetrahydride in diethyl ether T=25°C; 5 h;
参考文献
Mimura; Hayashida; Nomiyama; Ikegami; Iida; Tamura; Hiyama; Ohishi
Chemical and Pharmaceutical Bulletin, 1993 , vol. 41, # 11 p. 1971 - 1986
参考文献
US6451804 B1, ;
US 6451804 B1
反应条件
potassium hydroxide in propan-1-ol 24 h; Heating;
参考文献
Teuber, Hans-Joachim; Tsaklakidis, Christos; Bats, Jan Willem
Liebigs Annalen der Chemie, 1990 , # 8 p. 781 - 787
反应条件
1: 87 percent / pyridine / CH2Cl2 / 10 h / 27 °C 2: 64 percent / NaN3 / dimethylformamide / 7 h / 75 °C 3: 98 percent / LiAlH4 / diethyl ether / 5 h / 25 °C View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 41, # 11 p. 1971 - 1986
反应条件
1: 64 percent / NaN3 / dimethylformamide / 7 h / 75 °C 2: 98 percent / LiAlH4 / diethyl ether / 5 h / 25 °C View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 41, # 11 p. 1971 - 1986