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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
97101-07-0
合成路线
(共 6 条)
97101-07-0
→
反应条件
104873-15-6
反应条件
Multi-step reaction with 4 steps 1: 1,1'-carbonyldiimidazole / acetonitrile2: hydrogenchloride; water / ethyl acetate3: triethylamine / ethyl acetate; toluene4: dirhodium(II) tetraoctanoate / acetone / Reflux
参考文献
ORCHID CHEMICALS AND PHARMACEUTICALS LIMITED; KARALE, Sanjay Nivrutti; JANGALE, Arvind Atamaram; KALDATE, Ram Dattatraya Patent: WO2011/141847 A1, 2011 ;
97101-07-0
→
反应条件
105318-05-6
反应条件
Multi-step reaction with 3 steps 1: 90 percent / K2CO3 / acetone / 4 h / Heating2: 100 percent / NaH / tetrahydrofuran / 2 h / 0 °C3: 100 percent / H2 / 10percent Pd/C / ethanol / 760 Torr / Ambient temperature
参考文献
Sunagawa; Sasaki; Matsumura; Goda; Tamoto Chemical and Pharmaceutical Bulletin, 1994 , vol. 42, # 7 p. 1381 - 1387
97101-07-0
→
反应条件
105318-06-7
反应条件
Multi-step reaction with 5 steps 1: 90 percent / K2CO3 / acetone / 4 h / Heating2: 100 percent / NaH / tetrahydrofuran / 2 h / 0 °C3: 100 percent / H2 / 10percent Pd/C / ethanol / 760 Torr / Ambient temperature4: Et3N / CH2Cl2 / 1 h5: CH2Cl2 / 1 h
参考文献
Sunagawa; Sasaki; Matsumura; Goda; Tamoto Chemical and Pharmaceutical Bulletin, 1994 , vol. 42, # 7 p. 1381 - 1387
97101-07-0
→
反应条件
105318-32-9
反应条件
Multi-step reaction with 8 steps 1: 90 percent / K2CO3 / acetone / 4 h / Heating2: 100 percent / NaH / tetrahydrofuran / 2 h / 0 °C3: 100 percent / H2 / 10percent Pd/C / ethanol / 760 Torr / Ambient temperature4: Et3N / CH2Cl2 / 1 h5: CH2Cl2 / 1 h6: 86 percent / anisole, TiCl4 / CH2Cl2 / 1 h / 0 °C7: 93 percent / γ-collidine / dimethylformamide / 1.5 h / 65 °C8: 98 percent / Et3N / toluene / 5 h / Ambient temperature
参考文献
Sunagawa; Sasaki; Matsumura; Goda; Tamoto Chemical and Pharmaceutical Bulletin, 1994 , vol. 42, # 7 p. 1381 - 1387
1224732-95-9
→
反应条件
97101-07-0
反应条件
Stage #1: With lithium hydroxide hydrate; water; dihydrogen peroxide in tetrahydrofuran T=0°C; 1 h; Stage #2: With sodium sulfite in tetrahydrofuran; water Stage #3: With hydrogenchloride in water Show Experimental Procedure
参考文献
ACS DOBFAR S.p.A.; FRECCERO, Mauro; FOGLIATO, Giovanni; MANCA, Antonio; BASSANINI, Michele Patent: WO2010/49233 A1, 2010 ; Location in patent: Page/Page column 15 ;
114341-94-5
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反应条件
97101-07-0
反应条件
With sodium hydroxide in water; tert-butyl alcohol 72 h; Ambient temperature;
参考文献
Ito; Sasaki; Tamoto; Sunagawa; Terashima Tetrahedron, 1991 , vol. 47, # 16-17 p. 2801 - 2820