1,2,3,4-四氢-1-(2-氟苯基)-6-甲氧基-2-苯基异喹啉合成路线 （共 6 条）
反应条件
sodium tetrahydroborate in methanol
Yield given;
参考文献
Nagarajan, K.; Talwalker, P. K.; Kulkarni, C. L.; Shah, R. K.; Shenoy, S. J.; Prabhu, S. S.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1985 , vol. 24, p. 83 - 97
反应条件
1: SOCl2 / benzene / 1 h / Heating
2: diethyl ether / Ambient temperature
3: 74 percent / LAH / dioxane; diethyl ether
4: 1.) SOCl2 / 1.) benzene, reflux, 2.) ether, r.t.
5: 1.) POCl3, 2.) KI / 1.) reflux, 2.) H2O
6: NaBH4 / methanol
View Scheme
参考文献
Nagarajan, K.; Talwalker, P. K.; Kulkarni, C. L.; Shah, R. K.; Shenoy, S. J.; Prabhu, S. S.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1985 , vol. 24, p. 83 - 97
反应条件
1: 1.) SOCl2 / 1.) benzene, reflux, 2.) ether, r.t.
2: 1.) POCl3, 2.) KI / 1.) reflux, 2.) H2O
3: NaBH4 / methanol
View Scheme
参考文献
Nagarajan, K.; Talwalker, P. K.; Kulkarni, C. L.; Shah, R. K.; Shenoy, S. J.; Prabhu, S. S.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1985 , vol. 24, p. 83 - 97
反应条件
1: 74 percent / LAH / dioxane; diethyl ether
2: 1.) SOCl2 / 1.) benzene, reflux, 2.) ether, r.t.
3: 1.) POCl3, 2.) KI / 1.) reflux, 2.) H2O
4: NaBH4 / methanol
View Scheme
参考文献
Nagarajan, K.; Talwalker, P. K.; Kulkarni, C. L.; Shah, R. K.; Shenoy, S. J.; Prabhu, S. S.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1985 , vol. 24, p. 83 - 97
反应条件
1: 1.) POCl3, 2.) KI / 1.) reflux, 2.) H2O
2: NaBH4 / methanol
View Scheme
参考文献
Nagarajan, K.; Talwalker, P. K.; Kulkarni, C. L.; Shah, R. K.; Shenoy, S. J.; Prabhu, S. S.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1985 , vol. 24, p. 83 - 97
反应条件
1: diethyl ether / Ambient temperature
2: 74 percent / LAH / dioxane; diethyl ether
3: 1.) SOCl2 / 1.) benzene, reflux, 2.) ether, r.t.
4: 1.) POCl3, 2.) KI / 1.) reflux, 2.) H2O
5: NaBH4 / methanol
View Scheme
参考文献
Nagarajan, K.; Talwalker, P. K.; Kulkarni, C. L.; Shah, R. K.; Shenoy, S. J.; Prabhu, S. S.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1985 , vol. 24, p. 83 - 97
