4-(叔丁基二甲基甲硅烷基氧基)哌啶合成路线 （共 9 条）
反应条件
1H-imidazole in dichloromethane
T=20°C; 12 h;
参考文献
ELI LILLY AND COMPANY; BLANCO-PILLADO, Maria-Jesus; VETMAN, Tatiana Natali; FISHER, Matthew Joseph; KUKLISH, Steven Lee
Patent: WO2014/4230 A1, 2014 ;
Location in patent: Page/Page column 9; 10; 46 ;
反应条件
hydrogen; palladium hydroxide on carbon in methanol
P=760.051 Torr; 16 h;
参考文献
ALI, Amjad; Lo, Michael Man-Chu; Whitehead, Brent; Shah, Shrenik K.; Yan, Lin; Henderson, Timothy J.; Guo, Zack Zhiqiang
Patent: US2012/232039 A1, 2012 ;
Location in patent: Page/Page column 18 ;
反应条件
pyridine in (2S)-N-methyl-1-phenylpropan-2-amine hydrate; dichloromethane
参考文献
MOCHIDA PHARMACEUTICAL CO., LTD.
Patent: EP1048652 A1, 2000 ;
EP 1048652 A1
反应条件
bromo-1,3,2-benzodioxaborole in dichloromethane
0.5 h; Ambient temperature;
参考文献
Li, Bryan; Bemish, Raymond; Buzon, Richard A.; Chiu, Charles K.-F.; Colgan, Stephen T.; Kissel, William; Le, Tung; Leeman, Kyle R.; Newell, Lisa; Roth, Joshua
Tetrahedron Letters, 2003 , vol. 44, # 44 p. 8113 - 8115
反应条件
samarium diiodide; water; triethylamine in tetrahydrofuran
T=20°C; Inert atmosphere;
参考文献
Ankner, Tobias; Said Stalsmeden, Anna; Hilmersson, Goeran
Chemical Communications, 2013 , vol. 49, # 61 p. 6867 - 6869
反应条件
bromo-1,3,2-benzodioxaborole in dichloromethane
2 h; Ambient temperature;
参考文献
Boeckman, Robert K.; Potenza, Joan C.
Tetrahedron Letters, 1985 , vol. 26, # 11 p. 1411 - 1414
反应条件
1: 1H-imidazole / N,N-dimethyl-formamide / 1.5 h
2: hydrogen / palladium hydroxide on carbon / methanol / 16 h / 760.05 Torr
View Scheme
参考文献
ALI, Amjad; Lo, Michael Man-Chu; Whitehead, Brent; Shah, Shrenik K.; Yan, Lin; Henderson, Timothy J.; Guo, Zack Zhiqiang
Patent: US2012/232039 A1, 2012 ;
反应条件
1: 1H-imidazole / N,N-dimethyl-formamide / 1.5 h
2: hydrogen / palladium hydroxide on carbon / methanol / 16 h / 760.05 Torr
View Scheme
参考文献
ALI, Amjad; Lo, Michael Man-Chu; Whitehead, Brent; Shah, Shrenik K.; Yan, Lin; Henderson, Timothy J.; Guo, Zack Zhiqiang
Patent: US2012/232039 A1, 2012 ;
反应条件
N-ethyl-N,N-diisopropylamine in dichloromethane
T=20°C;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2004/6926 A1, 2004 ;
Location in patent: Page/Page column 56; 57 ;
WO 2004/006926 A1
