1.1: pyridine / 0 - 20 °C 2.1: boron trifluoride diethyl etherate / chloroform / 0.17 h / 0 - 20 °C / Inert atmosphere 2.2: 2 h / 20 °C / Inert atmosphere 3.1: methanol; sodium methylate / 1.5 h / 20 °C / pH 9 4.1: toluene-4-sulfonic acid / N,N-dimethyl-formamide / 20 - 50 °C 5.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / Inert atmosphere 5.2: 20 °C / Inert atmosphere 6.1: hydrogenchloride; sodium cyanoborohydride / tetrahydrofuran; diethyl ether / 5 h / 0 - 20 °C / Molecular sieve 7.1: N-iodo-succinimide; silver trifluoromethanesulfonate / dichloromethane / 0.17 h / 20 °C / Inert atmosphere View Scheme

1.1: methanol; sodium methylate / 1.5 h / 20 °C / pH 9 2.1: toluene-4-sulfonic acid / N,N-dimethyl-formamide / 20 - 50 °C 3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / Inert atmosphere 3.2: 20 °C / Inert atmosphere 4.1: hydrogenchloride; sodium cyanoborohydride / tetrahydrofuran; diethyl ether / 5 h / 0 - 20 °C / Molecular sieve 5.1: N-iodo-succinimide; silver trifluoromethanesulfonate / dichloromethane / 0.17 h / 20 °C / Inert atmosphere View Scheme

1.1: sodium hydroxide / water / 20 °C 2.1: pyridine / 0 - 20 °C 3.1: boron trifluoride diethyl etherate / chloroform / 0.17 h / 0 - 20 °C / Inert atmosphere 3.2: 2 h / 20 °C / Inert atmosphere 4.1: methanol; sodium methylate / 1.5 h / 20 °C / pH 9 5.1: toluene-4-sulfonic acid / N,N-dimethyl-formamide / 20 - 50 °C 6.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / Inert atmosphere 6.2: 20 °C / Inert atmosphere 7.1: hydrogenchloride; sodium cyanoborohydride / tetrahydrofuran; diethyl ether / 5 h / 0 - 20 °C / Molecular sieve 8.1: N-iodo-succinimide; silver trifluoromethanesulfonate / dichloromethane / 0.17 h / 20 °C / Inert atmosphere View Scheme

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / Inert atmosphere 1.2: 20 °C / Inert atmosphere 2.1: hydrogenchloride; sodium cyanoborohydride / tetrahydrofuran; diethyl ether / 5 h / 0 - 20 °C / Molecular sieve 3.1: N-iodo-succinimide; silver trifluoromethanesulfonate / dichloromethane / 0.17 h / 20 °C / Inert atmosphere View Scheme

1.1: toluene-4-sulfonic acid / N,N-dimethyl-formamide / 20 - 50 °C 2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / Inert atmosphere 2.2: 20 °C / Inert atmosphere 3.1: hydrogenchloride; sodium cyanoborohydride / tetrahydrofuran; diethyl ether / 5 h / 0 - 20 °C / Molecular sieve 4.1: N-iodo-succinimide; silver trifluoromethanesulfonate / dichloromethane / 0.17 h / 20 °C / Inert atmosphere View Scheme

1: hydrogenchloride; sodium cyanoborohydride / tetrahydrofuran; diethyl ether / 5 h / 0 - 20 °C / Molecular sieve 2: N-iodo-succinimide; silver trifluoromethanesulfonate / dichloromethane / 0.17 h / 20 °C / Inert atmosphere View Scheme

1: 1.) HgO, HgCl2, Drierite / 1.) dichloromethane, 1 h, r.t. 2.) 48 h 2: sodium methoxide, methanol / dioxane / 1 h / Ambient temperature 3: 4-toluenesulfonic acid / acetonitrile / 12 h / Ambient temperature 4: 1.) sodium hydride / 1.) N,N-dimethylformamide, 15 min, 0 deg C 2.) 1 h, 0 deg C; 3 h, r.t. 5: 70 percent / NaBH3CN, 3 Angstroem molecular sieves, HCl / tetrahydrofuran; diethyl ether / 5 h / Ambient temperature View Scheme

1: 85 percent / p-toluenesulphonic acid / acetonitrile 2: 86 percent / sodium hydride / 1,2-dimethoxy-ethane 3: 95 percent / molecular sieves, sodium cyanoborohydride, HCl / tetrahydrofuran; diethyl ether / 1 h / Ambient temperature View Scheme

1: 86 percent / sodium hydride / 1,2-dimethoxy-ethane 2: 95 percent / molecular sieves, sodium cyanoborohydride, HCl / tetrahydrofuran; diethyl ether / 1 h / Ambient temperature View Scheme

1: 95 percent / silver zeolite / CH2Cl2 / 1 h / Ambient temperature 2: 85 percent / sodium methoxide / methanol 3: 85 percent / p-toluenesulphonic acid / acetonitrile 4: 86 percent / sodium hydride / 1,2-dimethoxy-ethane 5: 95 percent / molecular sieves, sodium cyanoborohydride, HCl / tetrahydrofuran; diethyl ether / 1 h / Ambient temperature View Scheme