3-溴-8-氯-1,5-萘啶合成路线 （共 12 条）
反应条件
trichlorophosphate in dichloromethane
2.5 h; Reflux;
参考文献
Defaux, Julien; Antoine, Maud; Le Borgne, Marc; Schuster, Tilmann; Seipelt, Irene; Aicher, Babette; Teifel, Michael; Guenther, Eckhard; Gerlach, Matthias; Marchand, Pascal
ChemMedChem, 2014 , vol. 9, # 1 p. 217 - 232
反应条件
trichlorophosphate
2 h; Inert atmosphereReflux;
参考文献
Defaux, Julien; Antoine, Maud; Le Borgne, Marc; Schuster, Tilmann; Seipelt, Irene; Aicher, Babette; Teifel, Michael; Guenther, Eckhard; Gerlach, Matthias; Marchand, Pascal
ChemMedChem, 2014 , vol. 9, # 1 p. 217 - 232
反应条件
1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 18 h / 0 - 20 °C
2: trichlorophosphate / dichloromethane / 18 h / Reflux
View Scheme
参考文献
AETERNA ZENTARIS GMBH
Patent: WO2011/64250 A1, 2011 ;
反应条件
1.1: thionyl chloride / 8 h / |Inert atmosphere; |Reflux
2.1: ammonia / dichloromethane / 0.33 h / -30 °C
3.1: sodium hydroxide; bromine / water / 0.92 h / 0 - 80 °C
4.1: 1.5 h / 90 °C
4.2: 0.67 h / 60 - 70 °C
5.1: Dowtherm™ A / 0.17 h / 235 - 240 °C
6.1: trichlorophosphate / 2 h / |Inert atmosphere; |Reflux
View Scheme
参考文献
Defaux, Julien; Antoine, Maud; Le Borgne, Marc; Schuster, Tilmann; Seipelt, Irene; Aicher, Babette; Teifel, Michael; Guenther, Eckhard; Gerlach, Matthias; Marchand, Pascal
ChemMedChem, 2014 , vol. 9, # 1 p. 217 - 232
反应条件
1.1: ammonia / dichloromethane / 0.33 h / -30 °C
2.1: sodium hydroxide; bromine / water / 0.92 h / 0 - 80 °C
3.1: 1.5 h / 90 °C
3.2: 0.67 h / 60 - 70 °C
4.1: Dowtherm™ A / 0.17 h / 235 - 240 °C
5.1: trichlorophosphate / 2 h / |Inert atmosphere; |Reflux
View Scheme
参考文献
Defaux, Julien; Antoine, Maud; Le Borgne, Marc; Schuster, Tilmann; Seipelt, Irene; Aicher, Babette; Teifel, Michael; Guenther, Eckhard; Gerlach, Matthias; Marchand, Pascal
ChemMedChem, 2014 , vol. 9, # 1 p. 217 - 232
反应条件
1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 18 h / 0 - 20 °C
2: trichlorophosphate / dichloromethane / 2.5 h / |Reflux
View Scheme
参考文献
Defaux, Julien; Antoine, Maud; Le Borgne, Marc; Schuster, Tilmann; Seipelt, Irene; Aicher, Babette; Teifel, Michael; Guenther, Eckhard; Gerlach, Matthias; Marchand, Pascal
ChemMedChem, 2014 , vol. 9, # 1 p. 217 - 232
反应条件
1: thionyl chloride / 8 h / |Inert atmosphere; |Reflux
2: ammonia / dichloromethane / 0.33 h / -30 °C
3: sodium hydroxide; bromine / water / 0.92 h / 0 - 80 °C
4: sulfuric acid; iron sulphate heptahydrate; m-nitrobenzene sulfonic acid sodium salt; boric acid / water / 18 h / 135 °C
5: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 18 h / 0 - 20 °C
6: trichlorophosphate / dichloromethane / 2.5 h / |Reflux
View Scheme
参考文献
Defaux, Julien; Antoine, Maud; Le Borgne, Marc; Schuster, Tilmann; Seipelt, Irene; Aicher, Babette; Teifel, Michael; Guenther, Eckhard; Gerlach, Matthias; Marchand, Pascal
ChemMedChem, 2014 , vol. 9, # 1 p. 217 - 232
反应条件
1: ammonia / dichloromethane / 0.33 h / -30 °C
2: sodium hydroxide; bromine / water / 0.92 h / 0 - 80 °C
3: sulfuric acid; iron sulphate heptahydrate; m-nitrobenzene sulfonic acid sodium salt; boric acid / water / 18 h / 135 °C
4: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 18 h / 0 - 20 °C
5: trichlorophosphate / dichloromethane / 2.5 h / |Reflux
View Scheme
参考文献
Defaux, Julien; Antoine, Maud; Le Borgne, Marc; Schuster, Tilmann; Seipelt, Irene; Aicher, Babette; Teifel, Michael; Guenther, Eckhard; Gerlach, Matthias; Marchand, Pascal
ChemMedChem, 2014 , vol. 9, # 1 p. 217 - 232
反应条件
1: sulfuric acid; iron sulphate heptahydrate; m-nitrobenzene sulfonic acid sodium salt; boric acid / water / 18 h / 135 °C
2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 18 h / 0 - 20 °C
3: trichlorophosphate / dichloromethane / 2.5 h / |Reflux
View Scheme
参考文献
Defaux, Julien; Antoine, Maud; Le Borgne, Marc; Schuster, Tilmann; Seipelt, Irene; Aicher, Babette; Teifel, Michael; Guenther, Eckhard; Gerlach, Matthias; Marchand, Pascal
ChemMedChem, 2014 , vol. 9, # 1 p. 217 - 232
反应条件
1: 6.0 g / quinoline / 1 h / Heating
2: 6.4 g / phosphoryl chloride / 10 h / Heating
View Scheme
参考文献
Barlin; Tan
Australian Journal of Chemistry, 1985 , vol. 38, # 3 p. 459 - 465
