反应条件
1: 2,6-difluoro-benzoic acid With 1,1'-carbonyldiimidazole in tetrahydrofuran
T=20°C; 6 h;
2: malonic acid ethyl ester monopotassium salt With magnesium chloride in tetrahydrofuran
T=20 - 60°C; 27 h; Reflux;
3: With hydrogenchloride in tetrahydrofuran; water
pH=< 2;
参考文献
MERCK SHARP and; DOHME CORP.; BESHORE, Douglas, C.; KUDUK, Scott, D.
Patent: WO2010/96338 A1, 2010 ;
Location in patent: Page/Page column 40; 41 ;
