2-三甲基甲硅烷基乙炔-3-吡啶甲腈合成路线 （共 6 条）
反应条件
sodium hydroxide in tetrahydrofuran 2 h; Ambient temperature;
参考文献
Combret, Yves; Torche, Jean-Jacques; Ple, Nelly; Duflos, Jack; Dupas, Georges; Bourguignon, Jean; Queguiner, Guy
Tetrahedron, 1991 , vol. 47, # 45 p. 9369 - 9382
反应条件
1.1: 14 h / 80 °C / Inert atmosphere 2.1: sodium carbonate; dihydrogen peroxide / water; acetone / 14 h / 20 °C 3.1: toluene-4-sulfonic acid / toluene / 14 h / Reflux 4.1: trichlorophosphate / 14 h / 100 °C 4.2: 0 °C / pH 6 - 7 View Scheme
参考文献
Sunovion Pharmaceuticals Inc.
Patent: US2012/178748 A1, 2012 ;
US 20120178748 A1
反应条件
1: 52 percent / methanol / 5 h / Heating 2: 73 percent / 3N Na2CO3, 15percent H2O2 / acetone / 6 h / Ambient temperature 3: 55 percent / TsOH / benzene / 20 h / Heating View Scheme
参考文献
Sunovion Pharmaceuticals Inc.
Patent: US2012/178748 A1, 2012 ;
US 20120178748 A1
反应条件
copper(l) iodide; triethylamine; bis-triphenylphosphine-palladium(II) chloride
T=100°C; 20 h;
参考文献
Combret, Yves; Torche, Jean-Jacques; Ple, Nelly; Duflos, Jack; Dupas, Georges; Bourguignon, Jean; Queguiner, Guy
Tetrahedron, 1991 , vol. 47, # 45 p. 9369 - 9382
反应条件
1: 52 percent / methanol / 5 h / Heating
2: 73 percent / 3N Na2CO3, 15percent H2O2 / acetone / 6 h / Ambient temperature
View Scheme
参考文献
Sunovion Pharmaceuticals Inc.
Patent: US2012/178748 A1, 2012 ;
US 20120178748 A1
反应条件
1.1: 14 h / 80 °C / Inert atmosphere
2.1: sodium carbonate; dihydrogen peroxide / water; acetone / 14 h / 20 °C
3.1: toluene-4-sulfonic acid / toluene / 14 h / Reflux
4.1: trichlorophosphate / 14 h / 100 °C
4.2: 0 °C / pH 6 - 7
5.1: sodium azide / N,N-dimethyl-formamide / 4 h / 80 °C
6.1: hydrogenchloride; SnCl2·2H2O / water; methanol / 5 h / Reflux
View Scheme
参考文献
Sunovion Pharmaceuticals Inc.
Patent: US2012/178748 A1, 2012 ;
US 20120178748 A1
