2-(2,2-二甲氧基乙基)烟酰胺合成路线 （共 5 条）
反应条件
1.1: toluene-4-sulfonic acid / toluene / 14 h / Reflux 2.1: trichlorophosphate / 14 h / 100 °C 2.2: 0 °C / pH 6 - 7 View Scheme
参考文献
Sunovion Pharmaceuticals Inc.
Patent: US2012/178748 A1, 2012 ;
US 20120178748 A1
反应条件
toluene-4-sulfonic acid in toluene 14 h; Reflux;
参考文献
Sunovion Pharmaceuticals Inc.
Patent: US2012/178748 A1, 2012 ;
Location in patent: Page/Page column 45 ;
US 20120178748 A1
反应条件
dihydrogen peroxide; sodium carbonate in methanol; water
T=20°C; 4.5 h;
参考文献
ABBOTT LABORATORIES
Patent: WO2008/133753 A2, 2008 ;
Location in patent: Page/Page column 80-81 ;
反应条件
1: 52 percent / methanol / 5 h / Heating
2: 73 percent / 3N Na2CO3, 15percent H2O2 / acetone / 6 h / Ambient temperature
View Scheme
参考文献
Sakamoto, Takao; Kondo, Yoshinori; Yamanaka, Hiroshi
Chemical & Pharmaceutical Bulletin, 1985 , vol. 33, # 2 p. 626 - 633
反应条件
1.1: toluene-4-sulfonic acid / toluene / 14 h / Reflux
2.1: trichlorophosphate / 14 h / 100 °C
2.2: 0 °C / pH 6 - 7
3.1: sodium azide / N,N-dimethyl-formamide / 4 h / 80 °C
4.1: hydrogenchloride; SnCl2·2H2O / water; methanol / 5 h / Reflux
View Scheme
参考文献
Sunovion Pharmaceuticals Inc.
Patent: US2012/178748 A1, 2012 ;
US 20120178748 A1
