4-氟-5-甲基-2-硝基苯胺合成路线 （共 6 条）
反应条件
water; potassium hydroxide in methanol T=60°C; 0.5 h;
参考文献
KALYPSYS, INC.; BORCHARDT, Allen; DAVIS, Robert; BEAUREGARD, Clay; BECKER, Daniel; GAMACHE, Daniel; NOBLE, Stewart, A.; HELLBERG, Mark, R.; KLIMKO, Peter, G.; ZHIHAI, Qui; PAYNE, Joseph, E.; YANNI, John
Patent: WO2011/112731 A2, 2011 ;
Location in patent: Page/Page column 100 ;
WO 2011/112731 A2
反应条件
1: H2 / Raney nickel / ethanol / Ambient temperature 2: 15.8 g / 0.83 h 3: 66 percent / HNO3 / 0.25 h 4: 97 percent / 86percent KOH / H2O; methanol / 0.5 h / 60 °C View Scheme
参考文献
Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, , vol. 39, # 3 p. 213 - 218
反应条件
1: 15.8 g / 0.83 h 2: 66 percent / HNO3 / 0.25 h 3: 97 percent / 86percent KOH / H2O; methanol / 0.5 h / 60 °C View Scheme
参考文献
Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, , vol. 39, # 3 p. 213 - 218
反应条件
1: 66 percent / HNO3 / 0.25 h 2: 97 percent / 86percent KOH / H2O; methanol / 0.5 h / 60 °C View Scheme
参考文献
Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, , vol. 39, # 3 p. 213 - 218
反应条件
hydrogen; nickel in ethanol Ambient temperature;
参考文献
Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, , vol. 39, # 3 p. 213 - 218
反应条件
1: 93 percent / H2 / Raney nickel / ethanol / Ambient temperature
3: 1.) H2, 3.) NH4OH / 1.) Raney nickel / 1.) EtOH, RT, 25 min, 2.) 3.5 h, 3.) H2O
View Scheme
参考文献
Grivas, Spiros
Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1985 , vol. 39, # 3 p. 213 - 218
