potassium carbonate in DMF (N,N-dimethyl-formamide) T=20°C; 18 h;

1: benzyl alcohol With sodium in tetrahydrofuran Inert atmosphere; 2: 7-(benzyloxy)-2,2-dimethyl-4H-benzo[d][1,3]dioxin-4-one in tetrahydrofuran T=20°C; 0.5 h; Inert atmosphere;

1.1: 4-(N,N-dimethlyamino)pyridine; thionyl chloride / ethylene glycol dimethyl ether / 20 °C 2.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C 3.1: sodium / tetrahydrofuran / Inert atmosphere 3.2: 0.5 h / 20 °C / Inert atmosphere View Scheme

1.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C 2.1: sodium / tetrahydrofuran / Inert atmosphere 2.2: 0.5 h / 20 °C / Inert atmosphere View Scheme

potassium hydroxide; water in ethanol 6 h; Heating / reflux;