5-甲基异噁唑-3-氨基甲酸叔丁酯合成路线 （共 2 条）
反应条件
1: 3-(Boc-amino)-5-methylisoxazole With n-butyllithium in tetrahydrofuran T=-78 - 20°C; Metallation; 2: methyl iodide in tetrahydrofuran T=-78°C; Methylation;
参考文献
TORRENT PHARMACEUTICALS LTD
Patent: WO2007/100295 A1, 2007 ;
Location in patent: Page/Page column 35; 46; 57; 67; 74-75; 84; 92-93; 104; 114-115 ;
WO 2007/100295 A1
反应条件
1: n-BuLi / tetrahydrofuran / from -78 deg C up to 25 deg C 2: tetrahydrofuran / 25 °C / also with other electrophiles View Scheme
参考文献
Konoike, Toshiro; Kanda, Yasuhiko; Araki, Yoshitaka
Tetrahedron Letters, 1996 , vol. 37, # 19 p. 3339 - 3342
