1-苄氧羰基-氮杂环丁烷-3-甲酸合成路线 （共 6 条）
反应条件
1: With sodium hydroxide in water T=0°C; 16 h; 2: With hydrogenchloride in water
参考文献
MERCK SHARP and DOHME LIMITED
Patent: WO2004/78750 A1, 2004 ;
Location in patent: Page 81 ;
WO 2004/078750 A1
反应条件
1: With sodium hydrogencarbonate in tetrahydrofuran; water T=20°C; 2: With hydrogenchloride in water
参考文献
BRISTOL-MYERS SQUIBB COMPANY; PITTS, William, J.; DYCKMAN, Alaric, J.; SPERGEL, Steven, H.; WATTERSON, Scott, Hunter
Patent: WO2010/85582 A1, 2010 ;
Location in patent: Page/Page column 38 ;
WO 2010/085582 A1
反应条件
methanol; sodium hydroxide T=20°C; 3 h;
参考文献
MERCK SHARP and DOHME CORP.; COX, Christopher, D.; BESHORE, Douglas, C.; KIM, June, J.; KUDUK, Scott, D.; MCVEAN, Carol; REGER, Thomas; SHEEN, Justin
Patent: WO2013/52395 A1, 2013 ;
Location in patent: Paragraph 38; 39 ;
反应条件
1: in methanol; hexanes; toluene T=0°C; 2: With acetic acid in methanol; hexanes; toluene
参考文献
MERCK SHARP and DOHME LIMITED
Patent: WO2004/78750 A1, 2004 ;
Location in patent: Page 81 ;
WO 2004/078750 A1
反应条件
in diethyl ether T=20°C; 4 h;
参考文献
Zhu, Gui-Dong; Gong, Jianchun; Gandhi, Virajkumar B.; Penning, Thomas D.; Giranda, Vincent L.
Patent: US2006/229289 A1, 2006 ;
Location in patent: Page/Page column 19 ;
反应条件
borane-THF in tetrahydrofuran
T=-40 - 20°C;
参考文献
Amgen Inc.
Patent: US2003/225106 A1, 2003 ;
Location in patent: Page 96 ;
