三丁基(1-乙氧基乙烯)锡合成路线 （共 67 条）
反应条件
hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride in toluene T=100°C; 20 h;
参考文献
Kosugi, Masanori; Sumiya, Takashi; Obara, Yukimasa; Suzuki, Motohiro; Sano, Hiroshi; Migita, Toshihiko
Bulletin of the Chemical Society of Japan, 1987 , vol. 60, # 2 p. 767 - 768
反应条件
hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride in toluene T=100°C; 20 h;
参考文献
Bulletin of the Chemical Society of Japan, , vol. 60, # 2 p. 767 - 768
反应条件
1: With bis-triphenylphosphine-palladium(II) chloride in toluene Inert atmosphereReflux; 2: With potassium fluoride in toluene 0.5 h; 3: With hydrogenchloride; water in toluene T=70°C; 2 h;
参考文献
JANSSEN PHARMACEUTICA NV; MEERPOEL, Lieven; MAES, Louis, Jules, Roger, Marie; DE WIT, Kelly
Patent: WO2011/154298 A1, 2011 ;
Location in patent: Page/Page column 36-37 ;
WO 2011/154298 A1
反应条件
tris(dibenzylideneacetone)dipalladium (0); P(furyl)3 in N,N-dimethyl-formamide T=75 - 80°C; 4 h;
参考文献
Dainippon Sumitomo Pharma Co., Ltd.
Patent: EP2272844 A1, 2011 ;
Location in patent: Page/Page column 9-10 ;
反应条件
pyridine; tris(dibenzylideneacetone)dipalladium(0) chloroform complex; Rink amide resin; triphenylarine; trifluoroacetic acid 1.) CH2Cl2, room temp., 15 h, 2.) NMP, 70 deg C, 15 h, 3.) CH2Cl2, 15 min; Yield given. Multistep reaction;
参考文献
Beaver; Siegmund; Spear
Tetrahedron Letters, 1996 , vol. 37, # 8 p. 1145 - 1148
反应条件
1: With bis-triphenylphosphine-palladium(II) chloride; potassium carbonate in water; N,N-dimethyl-formamide T=110°C; 1 h; Microwave irradiation; 2: With hydrogenchloride; water in methanol T=20°C;
参考文献
SANOFI; EL-AHMAD, Youssef; FILOCHE-ROMME, Bruno; GANZHORM, Axel; MARCINIAK, Gilbert; MUZET, Nicolas; RONAN, Baptiste; VIVET, Bertrand; ZERR, Véronique
Patent: WO2013/190123 A1, 2013 ;
Location in patent: Page/Page column 62 ;
反应条件
1: With Pd2(PPh3)2Cl2 in toluene 2 h; Heating / reflux; 2: With hydrogenchloride; water in toluene 0.5 h;
参考文献
Wyeth
Patent: US2008/45577 A1, 2008 ;
Location in patent: Page/Page column 17 ;
反应条件
hydrogenchloride; tetrakis(triphenylphosphine) palladium(0); lithium chloride 1.) THF, reflux, 22 h, 2.) THF, 18 h; Yield given. Multistep reaction;
参考文献
Uehling, David E.; Nanthakumar, Suganthini S.; Croom, Dallas; Emerson, David L.; Leitner, Peter P.; et al.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 7 p. 1106 - 1118
反应条件
hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride in toluene T=100°C; 20 h;
参考文献
Kosugi, Masanori; Sumiya, Takashi; Obara, Yukimasa; Suzuki, Motohiro; Sano, Hiroshi; Migita, Toshihiko
Bulletin of the Chemical Society of Japan, 1987 , vol. 60, # 2 p. 767 - 768
反应条件
1: With triphenylphosphine; bis(dibenzylideneacetone)-palladium(0) in toluene
T=110°C; Stille coupling reaction; 12 h;
2: With hydrogenchloride in toluene
T=20°C; 24 h;
参考文献
Legros, Jean-Yves; Primault, Gaelle; Fiaud, Jean-Claude
Tetrahedron, 2001 , vol. 57, # 13 p. 2507 - 2514
