三丁基(1-乙氧基乙烯)锡合成路线 （共 67 条）
反应条件
1: With bis-triphenylphosphine-palladium(II) chloride in toluene
T=95°C; 3 h;
2: With hydrogenchloride in 1,4-dioxane; water
T=20°C; 1 h;
参考文献
MERCK and CO., INC.
Patent: WO2007/64553 A2, 2007 ;
Location in patent: Page/Page column 57-58 ;
WO 2007/064553 A2
反应条件
1: With bis-triphenylphosphine-palladium(II) chloride in toluene
T=110°C; 3 h; Sealed tube;
2: With hydrogenchloride in tetrahydrofuran
T=20°C; 1 h;
参考文献
BRISTOL-MYERS SQUIBB COMPANY; PINTO, Donald J.; CORTE, James R.; GILLIGAN, Paul J.; FANG, Tianan; SMITH II, Leon M.; WANG, Yufeng; YANG, Wu; EWING, William R.
Patent: WO2013/22818 A1, 2013 ;
Location in patent: Paragraph 00349 ;
WO 2013/022818 A1
反应条件
hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride in toluene
T=80°C; 20 h;
参考文献
Kosugi, Masanori; Sumiya, Takashi; Obara, Yukimasa; Suzuki, Motohiro; Sano, Hiroshi; Migita, Toshihiko
Bulletin of the Chemical Society of Japan, 1987 , vol. 60, # 2 p. 767 - 768
反应条件
1: With bis-triphenylphosphine-palladium(II) chloride in tetrahydrofuran
T=80°C; 18 h;
2: With hydrogenchloride
0.5 h;
参考文献
Allergan, Inc.
Patent: US6683092 B1, 2004 ;
Location in patent: Page column 9 ;
反应条件
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride in toluene
T=100°C; 3 h; Inert atmosphere;
参考文献
CROWN BIOSCIENCE INC. (TAICANG); ZHANG, Deyi; ZHANG, Ruihao; ZHONG, Boyu; SHIH, Chuan
Patent: WO2014/418 A1, 2014 ;
Location in patent: Page/Page column 92 ;
反应条件
[PdBr(N-succinimidyl)(PPh3)2] in toluene
T=60°C; Stille cross-coupling; 20 h;
参考文献
Crawforth, Catherine M.; Fairlamb, Ian J. S.; Taylor, Richard J. K.
Tetrahedron Letters, 2004 , vol. 45, # 3 p. 461 - 465
反应条件
1: With bis-triphenylphosphine-palladium(II) chloride; tetraethylammonium chloride in N,N-dimethyl-formamide
T=100°C; 3 h; Inert atmosphere;
2: With hydrogenchloride in methanol; N,N-dimethyl-formamide
T=20°C; 1 h; Inert atmosphere;
参考文献
Tagawa, Shinji; Choshi, Tominari; Okamoto, Asuka; Nishiyama, Takashi; Watanabe, Shiroh; Hatae, Noriyuki; Ishikura, Minoru; Hibino, Satoshi
European Journal of Organic Chemistry, 2013 , # 9 p. 1805 - 1810
反应条件
tri-tert-butyl phosphine; cesium fluoride; tris(dibenzylideneacetone)dipalladium (0) in 1,4-dioxane
T=100°C; Substitution; Stille cross-coupling reaction; 48 h;
参考文献
Littke, Adam F.; Fu, Gregory C.
Angewandte Chemie - International Edition, 1999 , vol. 38, # 16 p. 2411 - 2413
反应条件
1: With bis-triphenylphosphine-palladium(II) chloride in toluene
T=100°C;
2: With hydrogenchloride in water; toluene
1.5 h;
参考文献
PFIZER PRODUCTS INC.
Patent: WO2008/65508 A1, 2008 ;
Location in patent: Page/Page column 24 ;
反应条件
hydrogenchloride; potassium carbonate; bis(1,5-cyclooctadiene)nickel (0) in tetrahydrofuran; toluene
(N2 or Ar); aq. HCl added to a soln. of Sn compd. in THF, stirred at room temp. for 1 h, treated with solid K2CO3, a soln. of Ni complex in toluene and 1,2-heptadiene added, stirred at 80°C for 1 h; filtered, concd., chromd. (preparative GPC);
参考文献
Nakao, Yoshiaki; Shirakawa, Eiji; Tsuchimoto, Teruhisa; Hiyama, Tamejiro
Journal of Organometallic Chemistry, 2004 , vol. 689, # 23 p. 3701 - 3721
