三丁基(1-乙氧基乙烯)锡合成路线 （共 67 条）
反应条件
tetrakis(triphenylphosphine) palladium(0) in toluene
T=20°C; Stille Coupling; 10 h; Heating / reflux;
参考文献
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Patent: WO2007/38613 A2, 2007 ;
Location in patent: Page/Page column 52 ;
WO 2007/038613 A1
反应条件
1: With [(t-Bu)3PH]BF4; palladium diacetate in DMF (N,N-dimethyl-formamide)
T=120°C; 1 h;
2: With water in DMF (N,N-dimethyl-formamide); ethyl acetate
T=20°C;
参考文献
Altenbach, Robert J.; Black, Lawrence A.; Chang, Sou-Jen; Cowart, Marlon D.; Faghih, Ramin; Gfesser, Gregory A.; Ku, Yi-Yin; Liu, Huaqing; Lukin, Kirill A.; Nersesian, Diana L.; Pu, Yu-ming; Curtis, Michael P.
Patent: US2005/272736 A1, 2005 ;
Location in patent: Page/Page column 35 ;
US 20050272736 A1
反应条件
bis(triphenylphosphine)palladium(II)-chloride in N,N-dimethyl-formamide
T=80°C; 60 h;
参考文献
Zong, Ruifa; Wang, Dong; Hammitt, Richard; Thummel, Randolph P.
Journal of Organic Chemistry, 2006 , vol. 71, # 1 p. 167 - 175
反应条件
bis-triphenylphosphine-palladium(II) chloride in toluene
T=100°C;
参考文献
Akritopoulou-Zanze, Irini; Wakefield, Brian D.; Gasiecki, Alan; Kalvin, Douglas; Johnson, Eric F.; Kovar, Peter; Djuric, Stevan W.
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 5 p. 1480 - 1483
反应条件
1: With bis-triphenylphosphine-palladium(II) chloride in N,N-dimethyl-formamide
T=85°C; Inert atmosphereSealed tube;
2: With potassium fluoride in diethyl ether; N,N-dimethyl-formamide
T=20°C;
3: With hydrogenchloride in water; N,N-dimethyl-formamide; acetone
T=60°C; 2 h;
参考文献
F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; BROTHERTON-PLEISS, Christine, E.; CHEN, Zhi; ERICKSON, Shawn, David; KIM, Kyungjin; LI, Hongju; QIAN, Yimin; SO, Sung-Sau; WOVKULICH, Peter, Michael; YI, Lin
Patent: WO2014/56958 A1, 2014 ;
Location in patent: Paragraph 0076; 0077; 0078 ;
反应条件
1: With bis (triortho-tolylphosphine)palladium(II) chloride in toluene
2 h; Heating / reflux;
2: With hydrogenchloride in tetrahydrofuran; water
T=20°C; 16 h;
参考文献
Atkinson, Robert N.; Drizin, Irene; Gregg, Robert J.; Gross, Michael F.; Kort, Michael E.; Shi, Lei
Patent: US2004/220170 A1, 2004 ;
Location in patent: Page 18 ;
US 20040220170 A1
反应条件
1: With triphenylphosphine; bis(dibenzylideneacetone)-palladium(0) in toluene
T=110°C; Stille coupling reaction;
2: With hydrogenchloride in toluene
T=20°C; 12 h;
参考文献
Legros, Jean-Yves; Primault, Gaelle; Fiaud, Jean-Claude
Tetrahedron, 2001 , vol. 57, # 13 p. 2507 - 2514
反应条件
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide in acetonitrile
70 h; Heating / reflux;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2006/123113 A2, 2006 ;
Location in patent: Page/Page column 48 ;
WO 2006/123113 A2
反应条件
lithium chloride; bis(dibenzylideneacetone)-palladium(0) in N,N-dimethyl-formamide
T=23°C; 20 h;
参考文献
Valle, L. Del; Stille, J. K.; Hegedus, L. S.
Journal of Organic Chemistry, 1990 , vol. 55, p. 3019 - 3023
反应条件
1: With bis-triphenylphosphine-palladium(II) chloride in toluene
T=100°C; Inert atmosphere;
2: With potassium fluoride in toluene
T=20°C; 2 h;
参考文献
BRISTOL-MYERS SQUIBB COMPANY; BELEMA, Makonen; SRINIVASU, Pothukanuri; BENDER, John A.; LOPEZ, Omar D.; CHEN, Qi; RAMPULLA, Richard A.; GUPTA, Samayamunthula Venkata Satya Arun Kumar; MEANWELL, Nicholas A.
Patent: WO2012/21591 A1, 2012 ;
Location in patent: Page/Page column 114-115 ;
WO 2012/021591 A1
