3-三甲基硅烷噻吩-2-羧酸合成路线 （共 6 条）
反应条件
sodium hypochlorite; t-BU4(+)HSO4(-) in ethyl acetate
T=20°C; 12 h;
参考文献
Carpenter, Andrew J.; Chadwick, Derek J.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1985 , p. 173 - 182
反应条件
1: CH2Cl2 / 12 h / 20 °C
2: 83 percent / thionyl chloride / toluene / 12 h / 25 °C
3: 78 percent / 1.) nBuLi / 1.) hexane, -78 deg C, 2.) hexane, 20 deg C, 24 h
4: 88 percent / t-BU4(+)HSO4(-), 3M sodium hypochlorite / ethyl acetate / 12 h / 20 °C
View Scheme
参考文献
Carpenter, Andrew J.; Chadwick, Derek J.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1985 , p. 173 - 182
反应条件
1: 82 percent / thionyl chloride / 2 h / Heating
2: CH2Cl2 / 12 h / 20 °C
3: 83 percent / thionyl chloride / toluene / 12 h / 25 °C
4: 78 percent / 1.) nBuLi / 1.) hexane, -78 deg C, 2.) hexane, 20 deg C, 24 h
5: 88 percent / t-BU4(+)HSO4(-), 3M sodium hypochlorite / ethyl acetate / 12 h / 20 °C
View Scheme
参考文献
Carpenter, Andrew J.; Chadwick, Derek J.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1985 , p. 173 - 182
反应条件
1: 78 percent / 1.) nBuLi / 1.) hexane, -78 deg C, 2.) hexane, 20 deg C, 24 h
2: 88 percent / t-BU4(+)HSO4(-), 3M sodium hypochlorite / ethyl acetate / 12 h / 20 °C
View Scheme
参考文献
Carpenter, Andrew J.; Chadwick, Derek J.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1985 , p. 173 - 182
反应条件
1: 83 percent / thionyl chloride / toluene / 12 h / 25 °C
2: 78 percent / 1.) nBuLi / 1.) hexane, -78 deg C, 2.) hexane, 20 deg C, 24 h
3: 88 percent / t-BU4(+)HSO4(-), 3M sodium hypochlorite / ethyl acetate / 12 h / 20 °C
View Scheme
参考文献
Carpenter, Andrew J.; Chadwick, Derek J.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1985 , p. 173 - 182
参考文献
Carpenter, Andrew J.; Chadwick, Derek J
Tetrahedron Letters, 1985 , vol. 26, # 14 p. 1777 - 1780
