N-(2-氟-4-碘苯基)乙酰氨合成路线 （共 11 条）
反应条件
1: 64 percent / hexamethylphosphoric acid triamide / 3 h / 150 °C
2: 95 percent / SnCl2, HCl / diethyl ether; CH2Cl2 / 2 h
3: 1.) Mg / 1.) diethyl ether, 30 min, 2.) THF, diethyl ether, overnight, reflux
4: CrO3, conc. H2SO4 / acetone; H2O
5: 85 percent / conc. HCl / H2O / 1 h / Heating
6: Br2 / acetic acid
View Scheme
参考文献
Kruger; Keck; Noll; Pieper
Arzneimittel-Forschung/Drug Research, 1984 , vol. 34, # 11 A p. 1612 - 1624
