反应条件
1: 1.) Mg, BrCH2CH2Br, I2 / 1.) Et2O, reflux, 1 h, 2.) 16 h
2: conc. HCl / ethanol / 2 h / Heating
3: 83 percent / CH3ONa / dimethylformamide / 2 h / 35 °C
4: 84 percent / 1.5M NaOH, Bu4NHSO4, 2,6-di-t-butyl-4-methylphenol / H2O / 3 h / Heating
5: 94 percent / dimethylformamide / 1.5 h / 80 °C
View Scheme
参考文献
Jarman, Michael; McCague, Raymond
Journal of Chemical Research, Miniprint, 1985 , # 4 p. 1342 - 1388
