1: 3 percent / dimethylformamide / 0.5 h / 5 °C 2: 84 percent / 1.5M NaOH, Bu4NHSO4, 2,6-di-t-butyl-4-methylphenol / H2O / 3 h / Heating 3: 86 percent / methanol / 16 h / 65 °C View Scheme

1: 3 percent / dimethylformamide / 0.5 h / 5 °C 2: 1.) NaH / 1.) DMF, 2.) 50 deg C View Scheme

1: 3 percent / dimethylformamide / 0.5 h / 5 °C 2: 84 percent / 1.5M NaOH, Bu4NHSO4, 2,6-di-t-butyl-4-methylphenol / H2O / 3 h / Heating 3: 94 percent / dimethylformamide / 1.5 h / 80 °C View Scheme