5-(2-溴甲基)-2,2-二甲基-1,3-二氧六环合成路线 （共 13 条）
反应条件
carbon tetrabromide; triphenylphosphine in N,N-dimethyl-formamide T=0°C; 2 h;
参考文献
Zheng, Qi-Huang; Wang, Ji-Quan; Liu, Xuan; Fei, Xiangshu; Mock, Bruce H.; Glick-Wilson, Barbara E.; Sullivan, Michael L.; Raikwar, Sudhanshu P.; Gardner, Thomas A.; Kao, Chinghai; Hutchins, Gary D.
Synthetic Communications, 2004 , vol. 34, # 4 p. 689 - 704
反应条件
in water; N,N-dimethyl-formamide
参考文献
BEECHAM GROUP PLC
Patent: EP141927 B1, 1991 ;
反应条件
1: NaBH4 / 2-methyl-propan-2-ol; methanol 2: p-toluenesulfonic acid / tetrahydrofuran 3: CBr4; PPh3 / tetrahydrofuran / 0 °C View Scheme
参考文献
Journal of Labelled Compounds and Radiopharmaceuticals, , vol. 46, p. S112 - S112
反应条件
1: p-toluenesulfonic acid / tetrahydrofuran 2: CBr4; PPh3 / tetrahydrofuran / 0 °C View Scheme
参考文献
Journal of Labelled Compounds and Radiopharmaceuticals, , vol. 46, p. S112 - S112
反应条件
in N-methyl-acetamide; methanol
参考文献
BEECHAM GROUP PLC
Patent: EP141927 B1, 1991 ;
反应条件
1: K2CO3 / dimethylformamide 2: HCl View Scheme
参考文献
Wang, Ji-Quan; Zheng, Qi-Huang; Fei, Xiangshu; Mock, Bruce H.; Hutchins, Gary D.
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 22 p. 3933 - 3938
反应条件
1: 54 percent / K2CO3 / dimethylformamide / 5 h / 20 °C 2: 80 percent / aq. HCl / 2 h / Heating 3: 53 percent / 4-dimethylaminopyridine; Et3N / dimethylformamide / 6 h / 50 - 60 °C 4: 29 percent / pyridine / 21 h / 20 °C View Scheme
参考文献
Wang, Ji-Quan; Zheng, Qi-Huang; Fei, Xiangshu; Mock, Bruce H.; Hutchins, Gary D.
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 22 p. 3933 - 3938
反应条件
1: 64 percent / K2CO3 / dimethylformamide / 5 h / Ambient temperature 2: cyclohexene / 10percent Pd/C / ethanol / Heating 3: aq. HCl / ethanol; cyclohexene; methanol / 0.5 h / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 30, # 9 p. 1636 - 1642
反应条件
potassium carbonate in N,N-dimethyl-formamide
Ambient temperature;
参考文献
Harnden, M.R.; Jarvest, R.L.
Tetrahedron Letters, 1985 , vol. 26, # 35 p. 4265 - 4268
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=20°C; 5 h;
参考文献
Zheng, Qi-Huang; Wang, Ji-Quan; Liu, Xuan; Fei, Xiangshu; Mock, Bruce H.; Glick-Wilson, Barbara E.; Sullivan, Michael L.; Raikwar, Sudhanshu P.; Gardner, Thomas A.; Kao, Chinghai; Hutchins, Gary D.
Synthetic Communications, 2004 , vol. 34, # 4 p. 689 - 704
