5-(2-溴甲基)-2,2-二甲基-1,3-二氧六环合成路线 （共 13 条）
反应条件
1: 64 percent / K2CO3 / dimethylformamide / 5 h / Ambient temperature
3: aq. HCl / Ambient temperature
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参考文献
Harnden, Michael R.; Jarvest, Richard L.; Bacon, Teresa H.; Boyd, Malcolm R.
Journal of Medicinal Chemistry, 1987 , vol. 30, # 9 p. 1636 - 1642
反应条件
1: 64 percent / K2CO3 / dimethylformamide / 5 h / Ambient temperature
2: 72 percent / 2.0 M HCl / 1.25 h / Heating
3: 45 percent / dicyclohexylcarbodiimide, 4-(dimethylamino)pyridine / dimethylformamide / 64 h / Ambient temperature
View Scheme
参考文献
Harnden, Michael R.; Jarvest, Richard L.; Bacon, Teresa H.; Boyd, Malcolm R.
Journal of Medicinal Chemistry, 1987 , vol. 30, # 9 p. 1636 - 1642
反应条件
1: 64 percent / K2CO3 / dimethylformamide / 5 h / Ambient temperature
2: 72 percent / 2.0 M HCl / 1.25 h / Heating
3: 43 percent / dicyclohexylcarbodiimide, 4-(dimethylamino)pyridine / dimethylformamide / 0.67 h / Ambient temperature
View Scheme
参考文献
Harnden, Michael R.; Jarvest, Richard L.; Bacon, Teresa H.; Boyd, Malcolm R.
Journal of Medicinal Chemistry, 1987 , vol. 30, # 9 p. 1636 - 1642
