7-氟-1-甲基-2H-3,1-苯并恶嗪-2,4(1H)-二酮合成路线 （共 5 条）
反应条件
1: 1.) sodium hydride / 1) toluene, 70 - 75 deg C, 1 h; 2) toluene, 1 h, 30 deg C 2: 79.5 percent / piperidine, acetic acid / 2 h / Heating View Scheme
参考文献
Birch, Alan M.; Davies, Roy V.; Maclean, Lachlan; Robinson, Keith
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1994 , # 4 p. 387 - 392
反应条件
sodium hydride 1) toluene, 70 - 75 deg C, 1 h; 2) toluene, 1 h, 30 deg C; Yield given. Multistep reaction;
参考文献
Birch, Alan M.; Davies, Roy V.; Maclean, Lachlan; Robinson, Keith
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1994 , # 4 p. 387 - 392
反应条件
sodium hydride in N,N-dimethyl-formamide
T=20°C; 18 h; Inert atmosphere;
参考文献
D'Souza, Asha M.; Spiccia, Nadia; Basutto, Jose; Jokisz, Pawel; Wong, Leon S.-M.; Meyer, Adam G.; Holmes, Andrew B.; White, Jonathan M.; Ryan, John H.
Organic Letters, 2011 , vol. 13, # 3 p. 486 - 489
反应条件
1: 65 percent / copper (powder), copper(II) chloride dihydrate / H2O / 1) 75 - 80 deg C, 30 min; 2) reflux, 5 h
2: sodium carbonate / toluene; H2O / 19 h / Ambient temperature
View Scheme
参考文献
Birch, Alan M.; Davies, Roy V.; Maclean, Lachlan; Robinson, Keith
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1994 , # 4 p. 387 - 392
反应条件
sodium carbonate in water; toluene
19 h; Ambient temperature;
参考文献
Birch, Alan M.; Davies, Roy V.; Maclean, Lachlan; Robinson, Keith
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1994 , # 4 p. 387 - 392
