3-氯-2-甲基吡啶-4-胺合成路线 （共 5 条）
反应条件
chlorine in sulfuric acid
参考文献
US5250527 A1, ;
US 5250527 A
反应条件
sulfuric acid; chlorine T=0°C; 2 h;
参考文献
Ife; Dyke; Keeling; Meenan; Meeson; Parsons; Price; Theobald; Underwood
Journal of Medicinal Chemistry, 1989 , vol. 32, # 8 p. 1970 - 1977
反应条件
1: 96 percent / NaNO2, conc. HCl / 1) 0 to 5 deg C, 1 h, 2) 25 deg C, 2 h 2: m-chloroperbenzoic acid / CH2Cl2 / 16 h / 20 - 25 °C View Scheme
参考文献
Ife; Dyke; Keeling; Meenan; Meeson; Parsons; Price; Theobald; Underwood
Journal of Medicinal Chemistry, 1989 , vol. 32, # 8 p. 1970 - 1977
反应条件
hydrogenchloride; sodium nitrite 1) 0 to 5 deg C, 1 h, 2) 25 deg C, 2 h;
参考文献
Ife; Dyke; Keeling; Meenan; Meeson; Parsons; Price; Theobald; Underwood
Journal of Medicinal Chemistry, 1989 , vol. 32, # 8 p. 1970 - 1977
反应条件
1: 96 percent / NaNO2, conc. HCl / 1) 0 to 5 deg C, 1 h, 2) 25 deg C, 2 h
2: m-chloroperbenzoic acid / CH2Cl2 / 16 h / 20 - 25 °C
3: trifluoroacetic anhydride / 2 h / 15 - 20 °C
View Scheme
参考文献
Ife; Dyke; Keeling; Meenan; Meeson; Parsons; Price; Theobald; Underwood
Journal of Medicinal Chemistry, 1989 , vol. 32, # 8 p. 1970 - 1977
