5-二氟甲氧基-2-巯基-1H-苯并咪唑合成路线 （共 12 条）
反应条件
1: PEG-600 / 50 - 55 °C 2: nitric acid; sulfuric acid / 2 h / 20 - 25 °C 3: methanol / 3 h / |Reflux 4: hydrazine hydrate / 4 h / |Reflux 5: 4 h / |Reflux View Scheme
参考文献
Asian Journal of Chemistry, , vol. 25, # 14 p. 7959 - 7966
反应条件
1: nitric acid; sulfuric acid / 2 h / 20 - 25 °C 2: methanol / 3 h / |Reflux 3: hydrazine hydrate / 4 h / |Reflux 4: 4 h / |Reflux View Scheme
参考文献
Asian Journal of Chemistry, , vol. 25, # 14 p. 7959 - 7966
反应条件
1: methanol / 3 h / |Reflux 2: hydrazine hydrate / 4 h / |Reflux 3: 4 h / |Reflux View Scheme
参考文献
Asian Journal of Chemistry, , vol. 25, # 14 p. 7959 - 7966
反应条件
1: hydrazine hydrate / 4 h / |Reflux 2: 4 h / |Reflux View Scheme
参考文献
Asian Journal of Chemistry, , vol. 25, # 14 p. 7959 - 7966
参考文献
Asian Journal of Chemistry, , vol. 25, # 14 p. 7959 - 7966
反应条件
1: 4-chloro-2-(chloromethyl)-3-methoxypyridine With sodium methylate in methanol; toluene T=15 - 25°C; 1 h; 2: 5-difluoromethoxy-2-mercapto-1H-benzimidazole in methanol; toluene 0.5 h; 3: With sodium methylate in methanol; toluene T=15 - 35°C; 1 h;
参考文献
EP1518857 A1, ;
Page/Page column 5 ;
反应条件
sodium hydroxide in water; toluene T=55 - 65°C; 4 - 6 h;
参考文献
WO2007/12651 A1, ;
Page/Page column 15-16 ;
反应条件
potassium carbonate in N,N-dimethyl-formamide T=20°C;
参考文献
Ray, Purna C.; Mittapelli, Vasantha; Rohatgi, Amit; Tyagi, Om Dutt
Synthetic Communications, 2007 , vol. 37, # 17 p. 2861 - 2868
反应条件
sodium hydroxide in water; isopropyl alcohol T=20°C; 3 h;
参考文献
DONGWOO SYNTECH CO., LTD
Patent: WO2009/75516 A2, 2009 ;
Location in patent: Page/Page column 4 ;
反应条件
sodium hydroxide in water T=25 - 30°C; 4 - 5 h;
参考文献
DR. REDDY'S LABORTORIES, LTD.; DR. REDDY'S LABORATORIES, INC.
Patent: WO2008/45777 A2, 2008 ;
Location in patent: Page/Page column 25-26 ;
