5-二氟甲氧基-2-巯基-1H-苯并咪唑合成路线 (共 12 条)
反应条件
1: With sodium hydroxide; tetrabutylammomium bromide in dichloromethane; water T=25 - 30°C; 12 h; 2: With sodium hydroxide; sodium hypochlorite in dichloromethane; water T=0 - 8°C; 6 h; Product distribution / selectivity;
参考文献
CIPLA LIMITED; WAIN, Christopher, Paul
Patent: WO2006/64249 A2, 2006 ;
Location in patent: Page/Page column 8; 10 ;
反应条件
1: 2-hydroxymethyl-3,4-dimethoxypyridine hydrochloride With thionyl chloride in dichloromethane T=0 - 15°C; 1 h; 2: 5-difluoromethoxy-2-mercapto-1H-benzimidazole With sodium hydroxide; tetrabutylammomium bromide in dichloromethane; water T=10 - 30°C; pH=10 - 11; 12 h; 3: With sodium hydroxide; sodium hypochlorite in dichloromethane; water T=0 - 8°C; 6 h; Product distribution / selectivity;
参考文献
CIPLA LIMITED; WAIN, Christopher, Paul
Patent: WO2006/64249 A2, 2006 ;
Location in patent: Page/Page column 8; 10-11 ;