3-乙氧基-4-甲氧基苯甲酸甲酯合成路线 （共 7 条）
反应条件
1.1: HNO3; glacial AcOH / 0.75 h / 50 - 60 °C 2.1: Fe; aq. NH4Cl / methanol / 19 h / Heating 3.1: dimethylformamide / 2.3 h / Heating 4.1: n-BuLi / hexane; tetrahydrofuran / 0.33 h / -78 °C 4.2: hexane; tetrahydrofuran / 1 h / -78 °C 4.3: glacial acetic acid / tetrahydrofuran; hexane / -78 - 25 °C View Scheme
参考文献
Wissner; Berger; Boschelli; Brawner Floyd Jr.; Greenberger; Gruber; Johnson; Mamuya; Nilakantan; Reich; Shen; Tsou; Upeslacis; Yu Fen Wang; Wu; Ye; Zhang
Journal of Medicinal Chemistry, 2000 , vol. 43, # 17 p. 3244 - 3256
参考文献
Fujisawa Pharmaceutical Co., Ltd.
Patent: US6384080 B1, 2002 ;
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=100°C; Alkylation; 9 h;
参考文献
Wissner; Berger; Boschelli; Brawner Floyd Jr.; Greenberger; Gruber; Johnson; Mamuya; Nilakantan; Reich; Shen; Tsou; Upeslacis; Yu Fen Wang; Wu; Ye; Zhang
Journal of Medicinal Chemistry, 2000 , vol. 43, # 17 p. 3244 - 3256
参考文献
Fujisawa Pharmaceutical Co., Ltd.
Patent: US6384080 B1, 2002 ;
参考文献
Fujisawa Pharmaceutical Co., Ltd.
Patent: US6384080 B1, 2002 ;
参考文献
Fujisawa Pharmaceutical Co., Ltd.
Patent: US6384080 B1, 2002 ;
参考文献
Freudenberg et al.
Chemische Berichte, 1939 , vol. 72, p. 217,226
