2'-脱氧-5-(2-羟基乙基)-3',5'-二-O-(4-甲基苯甲酰)尿苷合成路线 （共 7 条）
反应条件
chloro-trimethyl-silane; sodium iodide in acetonitrile
Demethylation; 0.0166667 h;
参考文献
Yu, Chung-Shan; Oberdorfer, Franz
Synthesis, 1999 , # 12 p. 2057 - 2064
反应条件
1.1: 20 h / 20 °C
2.1: 100 percent / NaOMe / methanol / 1 h / 20 °C
3.1: BSA / CHCl3 / 0.17 h / 20 °C
3.2: TMSOTf / CHCl3 / 1 h / 20 °C
4.1: 90 percent / Me3SiCl; NaI / acetonitrile / 0.02 h
View Scheme
参考文献
Yu, Chung-Shan; Oberdorfer, Franz
Synthesis, 1999 , # 12 p. 2057 - 2064
反应条件
1.1: BSA / CHCl3 / 0.17 h / 20 °C
1.2: TMSOTf / CHCl3 / 1 h / 20 °C
2.1: 90 percent / Me3SiCl; NaI / acetonitrile / 0.02 h
View Scheme
参考文献
Yu, Chung-Shan; Oberdorfer, Franz
Synthesis, 1999 , # 12 p. 2057 - 2064
反应条件
1.1: BSA / CHCl3 / 0.17 h / 20 °C
1.2: TMSOTf / CHCl3 / 1 h / 20 °C
2.1: 90 percent / Me3SiCl; NaI / acetonitrile / 0.02 h
View Scheme
参考文献
Yu, Chung-Shan; Oberdorfer, Franz
Synthesis, 1999 , # 12 p. 2057 - 2064
反应条件
1.1: 100 percent / NaOMe / methanol / 1 h / 20 °C
2.1: BSA / CHCl3 / 0.17 h / 20 °C
2.2: TMSOTf / CHCl3 / 1 h / 20 °C
3.1: 90 percent / Me3SiCl; NaI / acetonitrile / 0.02 h
View Scheme
参考文献
Yu, Chung-Shan; Oberdorfer, Franz
Synthesis, 1999 , # 12 p. 2057 - 2064
反应条件
chloro-trimethyl-silane; trimethylsilyl trifluoromethanesulfonate; 1,1,1,3,3,3-hexamethyl-disilazane
1.) reflux, 3 h, 2.) CHCl3, RT, 1 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Griengl, Herfried; Bodenteich, Michael; Hayden, Walter; Wanek, Erich; Streicher, Wolfgang; et al.
Journal of Medicinal Chemistry, 1985 , vol. 28, # 11 p. 1679 - 1684
反应条件
copper(l) iodide; 1,1,1,3,3,3-hexamethyl-disilazane
参考文献
Zhang, Di; Xu, Liang; Wei, Xia; Li, Yaming; He, Junlin; Liu, Keliang
Nucleosides, Nucleotides and Nucleic Acids, 2009 , vol. 28, # 10 p. 924 - 942
