苯并[b]噻吩-2-基甲酮合成路线 （共 8 条）
反应条件
dipyridinium dichromate; pyridinium trifluoroacetate in dichloromethane
T=20°C;
参考文献
Mahboobi, Siavosh; Teller, Steffen; Pongratz, Herwig; Hufsky, Harald; Sellmer, Andreas; Botzki, Alexander; Uecker, Andrea; Beckers, Thomas; Baasner, Silke; Schaechtele, Christoph; Ueberall, Florian; Kassack, Matthias U.; Dove, Stefan; Boehmer, Frank-D.
Journal of Medicinal Chemistry, 2002 , vol. 45, # 5 p. 1002 - 1018
反应条件
hydrogenchloride in methanol
参考文献
Strekowski, Lucjan; Wydra, Roman L.; Cegla, Marek T.; Czarny, Agnieszka; Patterson, Steven
Journal of Organic Chemistry, 1989 , vol. 54, # 26 p. 6120 - 6123
反应条件
ytterbium trifluoromethanesulfonate in chloroform
T=80°C; Friedel-Crafts reaction; 5 h;
参考文献
Su, Weike; Jin, Can
Synthetic Communications, 2004 , vol. 34, # 23 p. 4249 - 4256
反应条件
1: benzo[b]thiophene With n-butyllithium in diethyl ether; hexane
T=-20 - 0°C; Inert atmosphere;
2: N,N-dimethylcarbamoyl chloride in diethyl ether; hexane
T=-55 - 0°C; Inert atmosphere;
参考文献
Nenajdenko; Balenkova; Chernichenko; Vshivenko
Russian Chemical Bulletin, 2012 , vol. 61, # 7 p. 1456 - 1462
Izv. Akad. Nauk, Ser. Khim., 2012 , # 7 p. 1441 - 1447,7
反应条件
1.1: n-BuLi; diisopropylamine / tetrahydrofuran / 0.5 h / 0 °C
1.2: 89 percent / tetrahydrofuran / -78 - 20 °C
2.1: 76 percent / pyridinium dichromate; pyridinium trifluoroacetate / CH2Cl2 / 20 °C
View Scheme
参考文献
Mahboobi, Siavosh; Teller, Steffen; Pongratz, Herwig; Hufsky, Harald; Sellmer, Andreas; Botzki, Alexander; Uecker, Andrea; Beckers, Thomas; Baasner, Silke; Schaechtele, Christoph; Ueberall, Florian; Kassack, Matthias U.; Dove, Stefan; Boehmer, Frank-D.
Journal of Medicinal Chemistry, 2002 , vol. 45, # 5 p. 1002 - 1018
反应条件
1.1: n-BuLi; diisopropylamine / tetrahydrofuran / 0.5 h / 0 °C
1.2: 89 percent / tetrahydrofuran / -78 - 20 °C
2.1: 76 percent / pyridinium dichromate; pyridinium trifluoroacetate / CH2Cl2 / 20 °C
View Scheme
参考文献
Mahboobi, Siavosh; Teller, Steffen; Pongratz, Herwig; Hufsky, Harald; Sellmer, Andreas; Botzki, Alexander; Uecker, Andrea; Beckers, Thomas; Baasner, Silke; Schaechtele, Christoph; Ueberall, Florian; Kassack, Matthias U.; Dove, Stefan; Boehmer, Frank-D.
Journal of Medicinal Chemistry, 2002 , vol. 45, # 5 p. 1002 - 1018
反应条件
1: 99 percent / DDQ
2: 95 percent / aq. HCl / methanol
View Scheme
参考文献
Strekowski, Lucjan; Wydra, Roman L.; Cegla, Marek T.; Czarny, Agnieszka; Patterson, Steven
Journal of Organic Chemistry, 1989 , vol. 54, # 26 p. 6120 - 6123
反应条件
n-butyllithium; chloro-trimethyl-silane
1.) THF, hexane, room temperature, 2.) -78 deg C to room temperature; Yield given. Multistep reaction;
参考文献
Fischer, Erik; Larsen, Jan; Christensen, Jorn B.; Fourmigue, Marc; Madsen, Hans G.; Harrit, Niels
Journal of Organic Chemistry, 1996 , vol. 61, # 20 p. 6997 - 7005
