4-氨基-3-甲基苯磺酸合成路线 （共 22 条）
反应条件
Einw. von Phosphorpentachlorid auf das Natriumsalz;
参考文献
Child; Smiles
Journal of the Chemical Society, 1926 , p. 2701
参考文献
Nevile; Winther
Chemische Berichte, 1880 , vol. 13, p. 1947
Journal of the Chemical Society, 1880 , vol. 37, p. 631
反应条件
1.1: pyridine / 2 h / 20 °C 2.1: sodium hydroxide / pyridine / 3 h / 20 °C 2.2: 2 h / -30 - 40 °C 3.1: ammonium hydroxide / tetrahydrofuran / 1 h / 0 - 20 °C View Scheme
参考文献
Sun, Xicheng; Qiu, Jian; Strong, Sarah A.; Green, Louis S.; Wasley, Jan W.F.; Blonder, Joan P.; Colagiovanni, Dorothy B.; Stout, Adam M.; Mutka, Sarah C.; Richards, Jane P.; Rosenthal, Gary J.
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 6 p. 2338 - 2342
参考文献
Claus; Immel
Justus Liebigs Annalen der Chemie, 1891 , vol. 265, p. 77
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Nevile; Winther
Chemische Berichte, 1880 , vol. 13, p. 1947
Journal of the Chemical Society, 1880 , vol. 37, p. 631
反应条件
Diazotization.Erhitzen der Diazoniumverbindung mit verd. Salpetersaeure;
参考文献
Datta; Varma
Journal of the Indian Chemical Society, 1927 , vol. 4, p. 323
Chem. Zentralbl., 1928 , vol. 99, # I p. 491
参考文献
Datta; Varma
Journal of the Indian Chemical Society, 1927 , vol. 4, p. 323
Chem. Zentralbl., 1928 , vol. 99, # I p. 491
反应条件
1.1: pyridine / 2 h / 20 °C 2.1: sodium hydroxide / pyridine / 3 h / 20 °C 2.2: 2 h / -30 - 40 °C 3.1: ammonium hydroxide / tetrahydrofuran / 1 h / 0 - 20 °C 4.1: hydrogenchloride / ethanol; water / 80 °C View Scheme
参考文献
Sun, Xicheng; Qiu, Jian; Strong, Sarah A.; Green, Louis S.; Wasley, Jan W.F.; Blonder, Joan P.; Colagiovanni, Dorothy B.; Stout, Adam M.; Mutka, Sarah C.; Richards, Jane P.; Rosenthal, Gary J.
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 6 p. 2338 - 2342
反应条件
1: (i) (diazotization), (ii) CuCl 2: PCl5 View Scheme
参考文献
Courtin,A.
Helvetica Chimica Acta, 1976 , vol. 59, p. 379 - 387
反应条件
sulfuric acid
T=150 - 170°C;
参考文献
Hasse
Justus Liebigs Annalen der Chemie, 1885 , vol. 230, p. 287
反应条件
1: Einw. von Phosphorpentachlorid auf das Natriumsalz
2: zinc; alcohol; hydrochloric acid
3: iron chloride; alcohol
4: concentrated hydrochloric acid
View Scheme
参考文献
Child; Smiles
Journal of the Chemical Society, 1926 , p. 2701
