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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
对氯三氟甲苯
合成路线
(共 292 条)
98-56-6
对氯三氟甲苯
→
反应条件
42134-71-4
1,2-[双-(4-三氟甲基)苯基]乙烷
反应条件
1: (i) EtMgBr, (ii) /BRN= 605365/, (iii) aq. H2SO4 2: (i) nBuLi, (ii) /BRN= 1101680/, (iii) H2, AcOH, PdO View Scheme
参考文献
Novotny; Collins; Starks
Journal of pharmaceutical sciences, 1973 , vol. 62, # 6 p. 910 - 913
629-05-0
1-辛炔
+
98-56-6
对氯三氟甲苯
→
反应条件
536973-41-8
反应条件
dichloro bis(acetonitrile) palladium(II); 2-(di-tert-butylphosphino)-1-(2,6-diisopropylphenyl)-1H-imidazole; sodium carbonate in toluene T=90°C; Sonogashira coupling; Inert atmosphere;
参考文献
Torborg, Christian; Huang, Jun; Schulz, Thomas; Schaeffner, Benjamin; Zapf, Alexander; Spannenberg, Anke; Borner, Armin; Beller, Matthias
Chemistry - A European Journal, 2009 , vol. 15, # 6 p. 1329 - 1336
→
反应条件
536973-41-8
反应条件
cesium fluoride; tris(dibenzylideneacetone)dipalladium (0); SIDip*HCl in 1,4-dioxane; ethylene glycol dimethyl ether Suzuki-Miyaura coupling; 3 h; Heating;
参考文献
Torres, Gloria Hernandez; Choppin, Sabine; Colobert, Francoise
European Journal of Organic Chemistry, 2006 , # 6 p. 1450 - 1454
108-22-5
乙酸异丙烯酯
+
98-56-6
对氯三氟甲苯
→
反应条件
55186-75-9
4-三氟甲基苯乙烯
反应条件
[2,2']bipyridinyl; tetra-n-butylammonium tetrafluoroborate; cobalt(II) dibromide in pyridine; acetonitrile T=20°C; Electrolysis;
参考文献
Gomes, Paulo; Gosmini, Corinne; Perichon, Jacques
Tetrahedron, 2003 , vol. 59, # 17 p. 2999 - 3002
78-94-4
丁烯酮
+
98-56-6
对氯三氟甲苯
→
反应条件
57132-19-1
反应条件
sodium bromide; niobium bromide in pyridine; N,N-dimethyl-formamide T=100°C; Electrochemical reaction;
参考文献
Condon, Sylvie; Dupre, Daniel; Falgayrac, Gilles; Nedelec, Jean-Yves
European Journal of Organic Chemistry, 2002 , # 1 p. 105 - 111
598-32-3
3-丁烯-2-醇
+
98-56-6
对氯三氟甲苯
→
反应条件
581-80-6
+
57132-18-0
+
57132-19-1
+
115665-92-4
反应条件
1: 3-hydroxy-1-butene With α-cyclohexylcyclohexanemethanamine; tetrabutylammomium bromide in N,N-dimethyl acetamide T=20°C; Heck reaction; 0.25 h; 2: 1-chloro-4-(trifluoromethyl)benzene With 4'-hydroxyacetophenone oxime palladacycle catalyst in N,N-dimethyl acetamide T=120°C; Heck reaction; 24 h; Further stages.;
参考文献
Alacid, Emilio; Najera, Carmen
Advanced Synthesis and Catalysis, 2007 , vol. 349, # 17-18 p. 2572 - 2584
98-56-6
对氯三氟甲苯
→
反应条件
581-90-8
反应条件
1.1: BuLi / hexane; tetrahydrofuran / 1 h / -75 °C 1.2: 75 percent / hexane; tetrahydrofuran / 25 °C 2.1: 82 percent / TiCl4; Zn / tetrahydrofuran / 2 h / Heating View Scheme
参考文献
Bailly, Frederic; Gottet, Fabrice; Schlosser, Manfred
Synthesis, 2005 , # 5 art. no. T11704SS, p. 791 - 797
693-04-9
+
98-56-6
对氯三氟甲苯
→
反应条件
61342-04-9
反应条件
Fe(S-2-naphthyl)2 in tetrahydrofuran T=0°C; 1 h; Inert atmosphere;
参考文献
Cahiez, Gerard; Gager, Olivier; Buendia, Julien; Patinote, Cindy
Chemistry - A European Journal, 2012 , vol. 18, # 19 p. 5860 - 5863
4426-47-5
+
98-56-6
对氯三氟甲苯
→
反应条件
61342-04-9
反应条件
tetrabutylammomium bromide; potassium carbonate; [1-cyclohexyl-3-(di-pyridin-2-yl-methyl)-urea][PdCl2] in water T=100°C; Suzuki-Miyaura coupling; 70 h;
参考文献
Najera, Carmen; Gil-Molto, Juan; Karlstroem, Sofia
Advanced Synthesis and Catalysis, 2004 , vol. 346, # 13-15 p. 1798 - 1811
693-03-8
+
98-56-6
对氯三氟甲苯
→
反应条件
61342-04-9
反应条件
nickel
参考文献
Tamao,K. et al.
Bulletin of the Chemical Society of Japan, 1976 , vol. 49, p. 1958 - 1969
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