3-氧代-1-环戊烷羧酸合成路线 （共 39 条）
反应条件
2: 93 percent / t-BuOK / 2-methyl-propan-2-ol; diethyl ether / 0.33 h / 25 °C 3: 87 percent / K2CO3 / dimethylformamide / 0.5 h / 25 °C 4: 99 percent / NaH / tetrahydrofuran; hexamethylphosphoric acid triamide / 1.) 25 deg C, 2 h 2.) reflux 16 h 5: O3 / CH2Cl2 / -78 °C 6: 89 percent / diethylamine / CHCl3 / Heating View Scheme
参考文献
Tetrahedron Letters, , vol. 22, # 26 p. 2447 - 2450
反应条件
caesium carbonate in N,N-dimethyl-formamide T=20°C; 18 h;
参考文献
Gruenenthal GmbH
Patent: US2008/306084 A1, 2008 ;
Location in patent: Page/Page column 48 ;
US 20080306084 A1
参考文献
Haworth; Perkin
Journal of the Chemical Society, 1908 , vol. 93, p. 575
反应条件
2: 98 percent / cation exchange resin / 24 h / Heating View Scheme
参考文献
Sung, Sun-Young; Frahm, August Wilhelm
Archiv der Pharmazie, 1996 , vol. 329, # 6 p. 291 - 300
反应条件
acetic acid T=20°C; 2 h; Heating / reflux;
参考文献
HUNTER-FLEMING LIMITED
Patent: WO2006/82409 A2, 2006 ;
Location in patent: Page/Page column 15-16 ;
反应条件
(-)-Brucine in water
Reflux;
参考文献
Ausmees, Kerti; Selyutina, Anastasia; Kuett, Kristel; Lippur, Kristin; Pehk, Tonis; Lopp, Margus; Zusinaite, Eva; Merits, Andres; Kanger, Tonis
Nucleosides, Nucleotides and Nucleic Acids, 2011 , vol. 30, # 11 p. 897 - 907
参考文献
Sung, Sun-Young; Frahm, August Wilhelm
Archiv der Pharmazie, 1996 , vol. 329, # 6 p. 291 - 300
反应条件
toluene-4-sulfonic acid; orthoformic acid triethyl ester in toluene
24 h; Reflux;
参考文献
ASTRAZENECA AB
Patent: US2009/275574 A1, 2009 ;
Location in patent: Page/Page column 22 ;
反应条件
potassium hydroxide; hydroxylamine hydrochloride; water
参考文献
Kay; Perkin
Journal of the Chemical Society, 1906 , vol. 89, p. 1647
