1: alpha-tocopherol hydrogen succinate With 4-methyl-morpholine; isobutyl chloroformate in tetrahydrofuran
T=0 - 20°C; 1.75 h;
2: (S)-(-)-2-pyrrolidone-5-carboxylic acid With triethylamine in tetrahydrofuran; DMF (N,N-dimethyl-formamide); water
T=0 - 20°C;
3: With hydrogenchloride in dichloromethane; water
参考文献
Sonus Pharmaceuticals, Inc.
Patent: US6858227 B1, 2005 ;
Location in patent: Page/Page column 6-7 ;