反应条件
1: 1.) magnesium, / 1.) THF, 45 min, 2.) THF, 0 deg C, 1 h 2: 94 percent / H2 / Rh<P(C6H5)3>3Cl / benzene / 23 h / Ambient temperature 3: 1.) N-chlorosuccinimide, dimethyl sulfide, 2.) triethylamine / 1.) toluene, -25 deg C, 5 h, 2.) toluene, 10 min; to r.t., 15 min 4: hydrogen, HCl / 10 percent palladium on carbon / methanol / 15 h / 2585.7 Torr / Ambient temperature 5: 1.) periodic acid, benzyltrimethylammonium hydroxide, 2.) conc. HCl / methanol; H2O / 24 h / Ambient temperature; 1.) pH= 6, 2.) pH= 2 View Scheme
参考文献
Lubell, William D.; Rapoport, Henry
Journal of the American Chemical Society, 1988 , vol. 110, # 22 p. 7447 - 7455
