2-(2-溴-5-甲氧基苯基)-[1,3]二氧戊环合成路线 （共 11 条）
反应条件
in tetrahydrofuran; hexane T=-78°C; 0.833333 h;
参考文献
ELI LILLY AND COMPANY
Patent: WO2004/43903 A1, 2004 ;
Location in patent: Page 31 ;
WO 2004/043903 A1
反应条件
1: With n-butyllithium in diethyl ether; hexane T=-75°C; 1 h; 2: With tri-isopropoxy-borane in diethyl ether; hexane T=20°C; 2.5 h; 3: With hydrogenchloride in diethyl ether; hexane 1.5 h; Heating; Further stages.;
参考文献
Kumar, Subodh
Journal of the Chemical Society. Perkin Transactions 1, 2001 , # 9 p. 1018 - 1023
反应条件
hydrogenchloride; n-butyllithium in diethyl ether; hexane (N2); addn. of a soln. of BuLi in hexane to a soln. of acetal in ether at -75°C, stirring for 1 h, addn. of boron compd., stirring at room temp. for 2.5 h, addn. of aq. HCl, refluxing for 1.5 h with stirring; sepn. of ppt., extn. with aq. NaOH, acidification of the ext.;
参考文献
Kumar, Subodh
Journal of the Chemical Society. Perkin Transactions 1, 2001 , # 9 p. 1018 - 1023
反应条件
toluene-4-sulfonic acid in toluene
12 h; Heating;
参考文献
ELI LILLY AND COMPANY
Patent: WO2004/43903 A1, 2004 ;
Location in patent: Page 30 - 31 ;
WO 2004/043903 A1
反应条件
p-toluenesulfonic acid monohydrate in ethylene glycol; benzene
参考文献
Merck and Co., Inc.
Patent: US4548941 A1, 1985 ;
US 4548941 A
反应条件
1: 3-methoxy-benzaldehyde With bromine in chloroform
Heating;
2: ethylene glycol With toluene-4-sulfonic acid in benzene
T=100°C;
参考文献
Lautens, Mark; Marquardt, Tzvetelina
Journal of Organic Chemistry, 2004 , vol. 69, # 14 p. 4607 - 4614
反应条件
1: 73 percent / Br2 / acetic acid / 24 h / 20 °C
2: 80 percent / PTSA / toluene / 24 h / Heating
View Scheme
参考文献
Lin, Ming-Yuan; Das, Arindam; Liu, Rai-Shung
Journal of the American Chemical Society, 2006 , vol. 128, # 29 p. 9340 - 9341
反应条件
in ethylene glycol; toluene
参考文献
Rhone-Poulenc Rorer Limited
Patent: US6211234 B1, 2001 ;
反应条件
1: 69 percent / Fe; HCl
2: t-BuONO; HBr
3: CuBr
4: TSA / benzene / 24 h / Heating
View Scheme
参考文献
Tsoungas, Petros G; Searcey, Mark
Tetrahedron Letters, 2001 , vol. 42, # 37 p. 6589 - 6592
反应条件
1: t-BuONO; HBr
2: CuBr
3: TSA / benzene / 24 h / Heating
View Scheme
参考文献
Tsoungas, Petros G; Searcey, Mark
Tetrahedron Letters, 2001 , vol. 42, # 37 p. 6589 - 6592
