2,6-二氯-4-碘吡啶合成路线 （共 18 条）
反应条件
1: With hydrogenchloride T=20°C; 24 h; 2: With potassium iodide; sodium nitrite 0.0833333 h; Further stages.;
参考文献
The Regents of the University Of California
Patent: WO2004/46103 A2, 2004 ;
Location in patent: Page 33-34; 39-40 ;
反应条件
1: With N-tetramethylpiperidine magnesium chloride; lithium chloride in tetrahydrofuran T=25°C; 0.1 h; 2: With iodine in tetrahydrofuran T=-30°C;
参考文献
Krasovskiy, Arkady; Krasovskaya, Valeria; Knochel, Paul
Angewandte Chemie - International Edition, 2006 , vol. 45, # 18 p. 2958 - 2961
反应条件
1: With n-butyllithium in tetrahydrofuran; hexane T=-75°C; 0.75 h; 2: With iodine in tetrahydrofuran; hexane T=-75°C; 0.25 h;
参考文献
Schlosser, Manfred; Bobbio, Carla; Rausis, Thierry
Journal of Organic Chemistry, 2005 , vol. 70, # 7 p. 2494 - 2502
反应条件
1: With lithium diisopropyl amide in tetrahydrofuran; hexane T=-75°C; 2 h; 2: With water; silica gel in hexane; dichloromethane
参考文献
Marzi, Elena; Bigi, Anna; Schlosser, Manfred
European Journal of Organic Chemistry, 2001 , # 7 p. 1371 - 1376
反应条件
lithium diisopropyl amide in tetrahydrofuran T=-78°C;
参考文献
Journal of Medicinal Chemistry, , vol. 54, # 19 p. 6691 - 6703
反应条件
1: With 2,2,6,6-tetramethyl-piperidine; n-butyllithium; C6H16N2*2Cl(1-)*Zn(2+) in tetrahydrofuran T=20°C; 2 h; Inert atmosphere; 2: With iodine in tetrahydrofuran Inert atmosphere; regioselective reaction;
参考文献
Chemistry - A European Journal, , vol. 17, # 47 p. 13284 - 13297
反应条件
potassium carbonate; tetrakis(triphenylphosphine) palladium(0) in N,N-dimethyl-formamide T=110°C; 3 h; Inert atmosphere;
参考文献
NIPPON SHINYAKU CO., LTD.
Patent: US2011/288065 A1, 2011 ;
Location in patent: Page/Page column 46 ;
US 20110288065 A1
反应条件
1: bromobenzene With n-butyllithium in tetrahydrofuran; hexane T=-78°C; 0.25 h; 2: With zinc(II) chloride in tetrahydrofuran; hexane 0.25 h; 3: 2,6-dichloro-4-iodo-pyridine With tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran; hexane Negishi coupling; 16 h; Heating;
参考文献
Fang, Albert G.; Mello, Jesse V.; Finney, Nathaniel S.
Organic Letters, 2003 , vol. 5, # 7 p. 967 - 970
反应条件
tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran 4 h;
参考文献
Mello, Jesse V.; Finney, Nathaniel S.
Organic Letters, 2001 , vol. 3, # 26 p. 4263 - 4265
反应条件
1: 98 percent / Pd(PPh3)4 / tetrahydrofuran; various solvent(s) / 4 h 2: 95 percent / NaH / dimethylformamide; various solvent(s) / 4 h / 90 °C 3: H2 / Pd/C / ethanol / 760.05 Torr View Scheme
参考文献
Mello, Jesse V.; Finney, Nathaniel S.
Organic Letters, 2001 , vol. 3, # 26 p. 4263 - 4265
