5-(7-(4-(4,5-二氢-4-甲基-2-恶唑基)苯氧基)庚基)-3-甲基-异恶唑合成路线 （共 6 条）
反应条件
1: 1.) n-butyllithium / 1.) THF, hexane, -70 deg C, 0.5 h, 2.) THF, a) -50 deg C, 1 h, b) 0 deg C, 3 h, c) room temp., overnight
2: 95 percent / HCl gas / diethyl ether / 0 - 20 °C
3: 1.) TEA / 1.) CH2Cl2, 1 h, 2.) 120 deg C, 1.5 h
View Scheme
参考文献
Diana; McKinlay; Otto; Akullian; Oglesby
Journal of Medicinal Chemistry, 1985 , vol. 28, # 12 p. 1906 - 1910
反应条件
1: K2CO3 / acetone
2: 1.) n-butyllithium / 1.) THF, hexane, -70 deg C, 0.5 h, 2.) THF, a) -50 deg C, 1 h, b) 0 deg C, 3 h, c) room temp., overnight
3: 95 percent / HCl gas / diethyl ether / 0 - 20 °C
4: 1.) TEA / 1.) CH2Cl2, 1 h, 2.) 120 deg C, 1.5 h
View Scheme
参考文献
Diana; McKinlay; Otto; Akullian; Oglesby
Journal of Medicinal Chemistry, 1985 , vol. 28, # 12 p. 1906 - 1910
反应条件
1: 1.) n-butyllithium / 1.) THF, hexane, -70 deg C, 0.5 h, 2.) THF, a) -50 deg C, 1 h, b) 0 deg C, 3 h, c) room temp., overnight
2: 95 percent / HCl gas / diethyl ether / 0 - 20 °C
3: 1.) TEA / 1.) CH2Cl2, 1 h, 2.) 120 deg C, 1.5 h
View Scheme
参考文献
Diana; McKinlay; Otto; Akullian; Oglesby
Journal of Medicinal Chemistry, 1985 , vol. 28, # 12 p. 1906 - 1910
反应条件
1: K2CO3 / acetone
2: 1.) n-butyllithium / 1.) THF, hexane, -70 deg C, 0.5 h, 2.) THF, a) -50 deg C, 1 h, b) 0 deg C, 3 h, c) room temp., overnight
3: 95 percent / HCl gas / diethyl ether / 0 - 20 °C
4: 1.) TEA / 1.) CH2Cl2, 1 h, 2.) 120 deg C, 1.5 h
View Scheme
参考文献
Diana; McKinlay; Otto; Akullian; Oglesby
Journal of Medicinal Chemistry, 1985 , vol. 28, # 12 p. 1906 - 1910
反应条件
1: 95 percent / HCl gas / diethyl ether / 0 - 20 °C
2: 1.) TEA / 1.) CH2Cl2, 1 h, 2.) 120 deg C, 1.5 h
View Scheme
参考文献
Diana; McKinlay; Otto; Akullian; Oglesby
Journal of Medicinal Chemistry, 1985 , vol. 28, # 12 p. 1906 - 1910
反应条件
TEA
1.) CH2Cl2, 1 h, 2.) 120 deg C, 1.5 h; Yield given. Multistep reaction;
参考文献
Diana; McKinlay; Otto; Akullian; Oglesby
Journal of Medicinal Chemistry, 1985 , vol. 28, # 12 p. 1906 - 1910
