1: 82 percent / N,N-diisopropylethylamine DIEA, HOBt / dimethylformamide / 0 - 20 °C 2: H2 / 5percent Pd/C / acetic acid; propan-2-ol / 760 Torr / Ambient temperature 3: 75 percent / N-methylmorpholine hydrochloride / dimethylformamide / 4 h / -10 - 0 °C / ' 4: H2 / 5percent Pd/C / acetic acid; propan-2-ol / 760 Torr / Ambient temperature 5: N-methylmorpholine NMM, N,N'-dicyclohexylcarbodiimide DCC, HOBt / dimethylformamide / 1.) 0 deg C, 2 h, 2.) RT, 24 h 6: trifluoroacetic acid TFA / CH2Cl2 / 1 h / 0 °C View Scheme