4-(2-吡啶基)-苯甲酸甲酯合成路线 （共 31 条）
反应条件
sodium hydroxide in methanol
参考文献
Novartis Finance Corporation
Patent: US5849911 A1, 1998 ;
US 5849911 A
反应条件
lithium aluminium tetrahydride in diethyl ether Ambient temperature;
参考文献
Terashima, Masanao; Seki, Koh-ichi; Yoshida, Chihiro; Ohkura, Kazue; Kanaoka, Yuichi
Chemical and Pharmaceutical Bulletin, 1985 , vol. 33, # 3 p. 1009 - 1015
反应条件
1: 5.4 mg / LiAlH4 / diethyl ether / Ambient temperature 2: 1.3 mg / H2 / Pd on charcoal (10percent) / ethanol / 760 Torr / Ambient temperature View Scheme
参考文献
Terashima, Masanao; Seki, Koh-ichi; Yoshida, Chihiro; Ohkura, Kazue; Kanaoka, Yuichi
Chemical and Pharmaceutical Bulletin, 1985 , vol. 33, # 3 p. 1009 - 1015
反应条件
tetra-n-butylammonium tetrafluoroborate; NiBr2bipy in N,N-dimethyl-formamide
T=60°C; Substitution; electroreduction; Electrochemical reaction;
参考文献
Gosmini, Corinne; Nedelec, Jean Yves; Perichon, Jacques
Tetrahedron Letters, 2000 , vol. 41, # 26 p. 5039 - 5042
反应条件
tetrakis(triphenylphosphine) palladium(0); sodium carbonate in ethanol; water; toluene
12 h; Inert atmosphereReflux;
参考文献
Mizuno, Hajime; Takaya, Jun; Iwasawa, Nobuharu
Journal of the American Chemical Society, 2011 , vol. 133, # 5 p. 1251 - 1253
反应条件
1: 4-iodo-benzoic acid methyl ester With isopropylmagnesium chloride in tetrahydrofuran
T=-40°C; 0.666667 h;
2: alpha-chloropyridine With 1,1'-bis-(diphenylphosphino)ferrocene; bis(dibenzylideneacetone)-palladium(0) in tetrahydrofuran
T=-40°C; 5 h;
参考文献
Bonnet, Veronique; Mongin, Florence; Trecourt, Francois; Queguiner, Guy; Knochel, Paul
Tetrahedron, 2002 , vol. 58, # 22 p. 4429 - 4438
反应条件
1: 4-iodo-benzoic acid methyl ester With isopropylmagnesium chloride in tetrahydrofuran
T=-40°C; 0.666667 h;
2: 2-bromo-pyridine With 1,1'-bis-(diphenylphosphino)ferrocene; bis(dibenzylideneacetone)-palladium(0) in tetrahydrofuran
T=-40°C; 5 h;
参考文献
Bonnet, Veronique; Mongin, Florence; Trecourt, Francois; Queguiner, Guy; Knochel, Paul
Tetrahedron, 2002 , vol. 58, # 22 p. 4429 - 4438
反应条件
manganese; NiBr2(2,2'-bipyridine); trifluoroacetic acid in N,N-dimethyl-formamide
T=20°C; 2 h;
参考文献
Gosmini, Corinne; Bassene-Ernst, Carine; Durandetti, Muriel
Tetrahedron, 2009 , vol. 65, # 31 p. 6141 - 6146
反应条件
2-methylamino-ethanol; copper(l) iodide; PdCl2dcpp in N,N-dimethyl-formamide
T=100°C; Suzuki-Miyaura Coupling; 16 h; Inert atmosphere;
参考文献
Sakashita, Shohei; Takizawa, Miho; Sugai, Juugaku; Ito, Hajime; Yamamoto, Yasunori
Organic Letters, 2013 , vol. 15, # 17 p. 4308 - 4311
反应条件
palladium on activated charcoal in 1,3,5-trimethyl-benzene
T=160°C; 5 h;
参考文献
Matsushita; Sakamoto; Murakami; Matsui
Synthetic Communications, 1994 , vol. 24, # 22 p. 3307 - 3313
