6-甲氧基-1H-吲哚-2-羧酸甲酯合成路线 （共 27 条）
反应条件
Rh2(O2CC3F7)4 in toluene T=40°C; 16 h;
参考文献
Stokes, Benjamin J.; Dong, Huijun; Leslie, Brooke E.; Pumphrey, Ashley L.; Driver, Tom G.
Journal of the American Chemical Society, 2007 , vol. 129, # 24 p. 7500 - 7501
反应条件
[Rh2(trifluoroacetate)4] in toluene T=95°C; 0.333333 h; Microwave irradiation;
参考文献
Ranasinghe, Nadeesha; Jones, Graham B.
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 6 p. 1740 - 1742
反应条件
1: MeONa 2: xylene / Heating View Scheme
参考文献
Synlett, , # 17 p. 2755 - 2758
反应条件
1: α-acetylaminoacrylic acid With triphenylphosphine; hydroxymethyl polystyrene resin; diethylazodicarboxylate in tetrahydrofuran; toluene T=20°C; 24 h; 2: 1,2-dibromo-4-methoxybenzene With tris(dibenzylideneacetone)dipalladium(0) chloroform complex; N,N-dicyclohexylmethylamine; [(t-Bu)3PH]BF4 in toluene Heck reaction; 3: sodium methylate in tetrahydrofuran; methanol T=20°C; 12 h;
参考文献
Journal of Organic Chemistry, , vol. 68, # 15 p. 6011 - 6019
反应条件
triethyl phosphite T=160°C; Yield given;
参考文献
Heterocycles, , vol. 48, # 8 p. 1513 - 1518
反应条件
1: potassium carbonate; potassium iodide / acetone / 12 h / 20 - 60 °C / |Inert atmosphere 2: 12 h / 120 °C / |Sealed tube; |Inert atmosphere 3: iodine / neat (no solvent) / 0.1 h / 20 °C View Scheme
参考文献
Arkivoc, , vol. 2014, # 3 p. 18 - 53
参考文献
Journal of Organic Chemistry, , vol. 68, # 15 p. 6011 - 6019
反应条件
1: With boron tribromide in dichloromethane T=0 - 20°C; 20 h; 2: With hydrogenchloride; water
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2008/157270 A1, 2008 ;
Location in patent: Page/Page column 77 ;
反应条件
1: 99 percent / aq. NaOH / Heating 2: 87 percent / Cu; quinoline / Heating View Scheme
参考文献
Allen; Hamaker; La Loggia; Cook
Synthetic Communications, 1992 , vol. 22, # 14 p. 2077 - 2102
反应条件
1: 93.9 percent / 2N aq. NaOH / 0.5 h / Heating 2: 97.6 percent / Cu / quinoline / 2 h / Heating 3: 1.) POCl3, 3.) aq. NaOH 4: 1.) NaH / 1.) THF, 40 deg C, 90 min, 2.) THF, RT, 18 h View Scheme
参考文献
Allen; Hamaker; La Loggia; Cook
Synthetic Communications, 1992 , vol. 22, # 14 p. 2077 - 2102
