1,3,8-三羟基-11H-苯并呋喃并[2,3-b][1]苯并吡喃-11-酮合成路线 （共 19 条）
反应条件
2,3-dicyano-5,6-dichloro-p-benzoquinone in tetrahydrofuran
T=60°C; 0.75 h; Inert atmosphere;
参考文献
Selepe, Mamoalosi A.; Drewes, Siegfried E.; Van Heerden, Fanie R.
Tetrahedron, 2011 , vol. 67, # 45 p. 8654 - 8658
反应条件
1: KOH / ethanol / 85 °C
2: hydrochloric acid
3: pyridine
4: thallium(III) nitrate trihydrate / CHCl3 / 2 h / 40 °C
5: aq. NaOH / tetrahydrofuran; methanol / 2 h / 35 °C
6: hydrogen / 5 percent Pd/C / dioxane; methanol / 8 h / 20 °C
7: 63 percent / 2,3-dichloro-5,6-dicyanobenzoquinone / tetrahydrofuran / 0.5 h / 50 °C
View Scheme
参考文献
Tsukayama, Masao; Oda, Akihiro; Kawamura, Yasuhiko; Nishiuchi, Masaki; Yamashita, Kazuyo
Tetrahedron Letters, 2001 , vol. 42, # 35 p. 6163 - 6166
反应条件
1: hydrogen / 5 percent Pd/C / dioxane; methanol / 8 h / 20 °C
2: 63 percent / 2,3-dichloro-5,6-dicyanobenzoquinone / tetrahydrofuran / 0.5 h / 50 °C
View Scheme
参考文献
Tsukayama, Masao; Oda, Akihiro; Kawamura, Yasuhiko; Nishiuchi, Masaki; Yamashita, Kazuyo
Tetrahedron Letters, 2001 , vol. 42, # 35 p. 6163 - 6166
反应条件
1: pyridine
2: thallium(III) nitrate trihydrate / CHCl3 / 2 h / 40 °C
3: aq. NaOH / tetrahydrofuran; methanol / 2 h / 35 °C
4: hydrogen / 5 percent Pd/C / dioxane; methanol / 8 h / 20 °C
5: 63 percent / 2,3-dichloro-5,6-dicyanobenzoquinone / tetrahydrofuran / 0.5 h / 50 °C
View Scheme
参考文献
Tsukayama, Masao; Oda, Akihiro; Kawamura, Yasuhiko; Nishiuchi, Masaki; Yamashita, Kazuyo
Tetrahedron Letters, 2001 , vol. 42, # 35 p. 6163 - 6166
反应条件
1: thallium(III) nitrate trihydrate / CHCl3 / 2 h / 40 °C
2: aq. NaOH / tetrahydrofuran; methanol / 2 h / 35 °C
3: hydrogen / 5 percent Pd/C / dioxane; methanol / 8 h / 20 °C
4: 63 percent / 2,3-dichloro-5,6-dicyanobenzoquinone / tetrahydrofuran / 0.5 h / 50 °C
View Scheme
参考文献
Tsukayama, Masao; Oda, Akihiro; Kawamura, Yasuhiko; Nishiuchi, Masaki; Yamashita, Kazuyo
Tetrahedron Letters, 2001 , vol. 42, # 35 p. 6163 - 6166
反应条件
1: aq. NaOH / tetrahydrofuran; methanol / 2 h / 35 °C
2: hydrogen / 5 percent Pd/C / dioxane; methanol / 8 h / 20 °C
3: 63 percent / 2,3-dichloro-5,6-dicyanobenzoquinone / tetrahydrofuran / 0.5 h / 50 °C
View Scheme
参考文献
Tsukayama, Masao; Oda, Akihiro; Kawamura, Yasuhiko; Nishiuchi, Masaki; Yamashita, Kazuyo
Tetrahedron Letters, 2001 , vol. 42, # 35 p. 6163 - 6166
反应条件
pyridine hydrochloride
Heating;
参考文献
Miller, Chris P.; Collini, Michael D.; Harris, Heather A.
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 14 p. 2399 - 2403
反应条件
1: AlCl3 / 1,2-dichloro-ethane
2: 68 percent / AlCl3 / CHCl3
3: 46 percent / morpholine
4: 86 percent / BBr3 / CH2Cl2
5: 32 percent / DDQ / tetrahydrofuran
6: 43 percent / Pyr*HCl / Heating
View Scheme
参考文献
Miller, Chris P.; Collini, Michael D.; Harris, Heather A.
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 14 p. 2399 - 2403
反应条件
1: 32 percent / DDQ / tetrahydrofuran
2: 43 percent / Pyr*HCl / Heating
View Scheme
参考文献
Miller, Chris P.; Collini, Michael D.; Harris, Heather A.
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 14 p. 2399 - 2403
反应条件
1: SOCl2 / tetrahydrofuran
2: AlCl3 / 1,2-dichloro-ethane
3: 68 percent / AlCl3 / CHCl3
4: 46 percent / morpholine
5: 86 percent / BBr3 / CH2Cl2
6: 32 percent / DDQ / tetrahydrofuran
7: 43 percent / Pyr*HCl / Heating
View Scheme
参考文献
Miller, Chris P.; Collini, Michael D.; Harris, Heather A.
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 14 p. 2399 - 2403
