(alphaS)-alpha-[[(1,1-二甲基乙氧基)羰基]氨基]-环己烷丙酸甲酯合成路线 （共 15 条）
反应条件
1.1: Zn; TMSCl / dimethylformamide / 0.33 h / 0 °C
1.2: 41 percent / Pd(PPh3)2Cl2 / dimethylformamide / 16 h / 50 °C
2.1: 96 percent / H2 / Pd/C / methanol / 24 h
View Scheme
参考文献
Carrillo-Marquez, Tomas; Caggiano, Lorenzo; Jackson, Richard F. W.; Grabowska, Urszula; Rae, Alastair; Tozer, Matthew J.
Organic and Biomolecular Chemistry, 2005 , vol. 3, # 22 p. 4117 - 4123
反应条件
1.1: 60 percent / pyridine / CH2Cl2 / 16 h / 0 - 20 °C
2.1: Zn; TMSCl / dimethylformamide / 0.33 h / 0 °C
2.2: CuCN; LiCl / dimethylformamide / 0.08 h / 0 °C
2.3: 40 percent / dimethylformamide / 16 h / -30 - 20 °C
3.1: 96 percent / H2 / Pd/C / methanol / 24 h
View Scheme
参考文献
Carrillo-Marquez, Tomas; Caggiano, Lorenzo; Jackson, Richard F. W.; Grabowska, Urszula; Rae, Alastair; Tozer, Matthew J.
Organic and Biomolecular Chemistry, 2005 , vol. 3, # 22 p. 4117 - 4123
反应条件
1: hydrogenchloride
2: 5 rhodium-on-charcoal; hydrogen / methanol; water / 16 h / 60 °C / 2828.7 - 3087.28 Torr
View Scheme
参考文献
Ager, David J.; Prakash, Indra
Organic Process Research and Development, 2003 , vol. 7, # 2 p. 164 - 167
反应条件
1: hydrogenchloride
2: 5 rhodium-on-charcoal; hydrogen / methanol; water / 16 h / 60 °C / 2828.7 - 3087.28 Torr
View Scheme
参考文献
Ager, David J.; Prakash, Indra
Organic Process Research and Development, 2003 , vol. 7, # 2 p. 164 - 167
反应条件
1: hydrogenchloride / methanol / 4 h / 20 °C
2: hydrogenchloride / 24 h / |Reflux
View Scheme
参考文献
Ager, David J.; Prakash, Indra
Organic Process Research and Development, 2003 , vol. 7, # 2 p. 164 - 167
