2,3-二氯-5-氨基吡啶合成路线 （共 8 条）
反应条件
iron; acetic acid in water 2 h; below 50 deg C;
参考文献
Koch; Schnatterer
Synthesis, 1990 , # 6 p. 499 - 501
反应条件
magnesium sulfate in water; acetic acid; ethyl acetate
参考文献
Hoechst Aktiengesellschaft
Patent: US4756739 A1, 1988 ;
参考文献
Abbott Laboratories
Patent: US6133253 A1, 2000 ;
反应条件
1: 93 percent / aq. KClO3, conc. HCl / 0.25 h / 50 - 60 °C 2: 98 percent / POCl3, quinoline / 2 h / 120 °C 3: 87 percent / Fe, AcOH / H2O / 2 h / below 50 deg C View Scheme
参考文献
Synthesis, , # 6 p. 499 - 501
反应条件
1: 98 percent / POCl3, quinoline / 2 h / 120 °C 2: 87 percent / Fe, AcOH / H2O / 2 h / below 50 deg C View Scheme
参考文献
Synthesis, , # 6 p. 499 - 501
反应条件
1: With hydrogen bromide; sodium nitrite in water T=0 - 5°C; 1.16667 h; 2: With copper(I) bromide in water T=0 - 20°C; 0.333333 h;
参考文献
Buckley, Michael J.; Ji, Jianguo
Patent: US2004/242641 A1, 2004 ;
Location in patent: Page 4 ;
US 20040242641 A1
反应条件
1: 1) HBF4, NaNO2 / 1) water, 0 deg C, 1 h, 2) 70 deg C, 1h 2: 96 percent / 2 N KOH / 0.5 h / 5 °C View Scheme
参考文献
Duplessis, Martin; Morency, Louis; James, Clint; Minville, Joannie; Deroy, Patrick; Morin, Sebastien; Thavonekham, Bounkham; Tremblay, Martin; Halmos, Ted; Simoneau, Bruno; Bousquet, Yves; Sturino, Claudio
Tetrahedron Letters, 2013 , vol. 54, # 19 p. 2303 - 2307
反应条件
pyridine; Ki in ethylene glycol dimethyl ether; acetonitrile; pentane
参考文献
Abbott Laboratories
Patent: US5733912 A1, 1998 ;
