2-溴-4,6-二氟苯酚合成路线 （共 14 条）
反应条件
1: water; potassium hydroxide / methanol / 24 h / Reflux 2: bromine / water / 2 h / 0 - 5 °C View Scheme
参考文献
Organic Process Research and Development, , vol. 16, # 4 p. 704 - 709
反应条件
1: 1,4-diaza-bicyclo[2.2.2]octane / 16 h / Reflux 2: sulfuric acid / acetic acid / 1 h / 100 °C 3: sodium hypochlorite; sodium hydroxide / methanol / 24 h / 25 °C 4: hydrogen / methanol / 20 h / 80 °C / 22502.3 Torr 5: water; potassium hydroxide / methanol / 24 h / Reflux 6: bromine / water / 2 h / 0 - 5 °C View Scheme
参考文献
Organic Process Research and Development, , vol. 16, # 4 p. 704 - 709
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=100°C; 2 h;
参考文献
BRISTOL-MYERS SQUIBB COMPANY; MATTSON, Ronald J.; MENG, Zhaoxing; GUERNON, Leatte R.
Patent: WO2013/192306 A1, 2013 ;
Location in patent: Page/Page column 90 ;
反应条件
potassium hydroxide; tetrabutylammomium bromide in tetrahydrofuran; water
T=64°C; 2 h;
参考文献
VITAE PHARMACEUTICALS, INC.
Patent: WO2007/70201 A1, 2007 ;
Location in patent: Page/Page column 160 ;
WO 2007/070201 A1
