in acetonitrile Heating; Yield given;

in acetonitrile 3 h; Heating;

1: 90 percent / acetonitrile / 3 h / Heating 2: 74.5 percent / NaH / acetonitrile 3: 76.5 percent / NH3 / methanol / 48 h / Ambient temperature 4: 97 percent / pyridine / 4 h / Ambient temperature 5: 56 percent / KF, N,O-bis(trimethylsilyl)acetamide / 18-crown-6 ether / acetonitrile / 12 h / Heating 6: 82 percent / NH3 / methanol / 12 h / Ambient temperature View Scheme

1: H2 / Pd/BaCO32 2: 170 °C View Scheme

1: 2-ethoxy-ethanol / 41 h / |Reflux 2: ammonium hydroxide; 10 Pd/C; hydrogen / water; ethanol / 12 h View Scheme

in acetonitrile 4 h; Inert atmosphereReflux;

in ethylene glycol dimethyl ether 24 h; Reflux;

1: acetonitrile / 1 h / Heating 2: NH3 / ethanol / 6 h / 105 °C View Scheme

hydrogen bromide; acetic acid in ethyl acetate; acetone T=-5°C; 3 h;

T=-40°C;