2-氨基-5-溴-1H-吡咯-3,4-二甲腈合成路线 （共 14 条）
参考文献
Middleton et al.
Journal of the American Chemical Society, 1958 , vol. 80, p. 2822,2826
反应条件
1: 64 percent / H2 / 5percent Pd/BaCO3 / methanol / 3 h / 2585.7 Torr
2: 48 h / 160 - 170 °C
3: 63 percent / HCO2H, Raney Ni / 2 h / 80 °C
View Scheme
参考文献
Gangjee, Aleem; Mavandadi, Farahnaz; Queener, Sherry F.; McGuire, John J.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 12 p. 2158 - 2165
反应条件
1: in acetonitrile
1 h; Heating;
2: With ammonia in ethanol
T=105°C; 6 h;
参考文献
Porcari, Anthony R.; Ptak, Roger G.; Borysko, Katherine Z.; Breitenbach, Julie M.; Drach, John C.; Townsend, Leroy B.
Nucleosides, Nucleotides and Nucleic Acids, 2003 , vol. 22, # 12 p. 2171 - 2193
反应条件
1: 90 percent / acetonitrile / 3 h / Heating
2: 74.5 percent / NaH / acetonitrile
3: 76.5 percent / NH3 / methanol / 48 h / Ambient temperature
4: 97 percent / pyridine / 4 h / Ambient temperature
5: 56 percent / KF, N,O-bis(trimethylsilyl)acetamide / 18-crown-6 ether / acetonitrile / 12 h / Heating
6: 82 percent / NH3 / methanol / 12 h / Ambient temperature
7: 75 percent / NH4OH, H2O2 / dioxane; methanol; H2O / 12 h / Ambient temperature
View Scheme
参考文献
Ramasamy; Robins; Revankar
Tetrahedron, 1986 , vol. 42, # 21 p. 5869 - 5878
