1,3-二溴-2-碘-5-硝基苯合成路线 （共 10 条）
参考文献
Senear et al.
Journal of Organic Chemistry, 1946 , vol. 11, p. 378,381
反应条件
T=180 - 220°C; Product distribution;
参考文献
Carlin; Swakon
Journal of the American Chemical Society, 1955 , vol. 77, p. 966,969
反应条件
sodium iodide in N-methyl-acetamide; water
参考文献
Chidambaram, Ramakrishnan; Kant, Joydeep; Weaver, Raymond E.; Yu, Jurong; Ghosh, Arun
Patent: US2003/157671 A1, 2003 ;
US 20030157671 A1
反应条件
hydrogen iodide in acetonitrile
T=60°C; 13 h;
参考文献
Barbero; Degani; Diulgheroff; Dughera; Fochi
Synthesis, 2001 , # 14 p. 2180 - 2190
反应条件
nitrosyl sulfuric acid; sulfuric acid
Diazotization.Behandlung der Diazoniumsalz-Loesung mit KI in Wasser;
参考文献
Schoutissen
Journal of the American Chemical Society, 1933 , vol. 55, p. 4541,4544
反应条件
1: butanol-(1)
2: Hydrogenation.Erwaermen des erhaltenen 2.6-Dibrom-N1.N1-dimethyl-p-phenylendiamins mit N-Acetyl-sulfanilylchlorid und Pyridin
3: aq.-ethanolic hydrochloric acid
View Scheme
参考文献
Senear et al.
Journal of Organic Chemistry, 1946 , vol. 11, p. 378,381
反应条件
1.1: 70 percent / Fe; CH2CO2H / 0.5 h / Heating
2.1: BF3*Et2O; t-BuONO / CH2Cl2 / 1 h / below 5 deg C
2.2: 79 percent / K2CO3 / CH2Cl2 / 20 °C
3.1: 89 percent / CuI; Et3N / Pd(PPh3)2Cl2 / 108 h / 80 °C
4.1: 92 percent / K2CO3 / methanol / 1.5 h / 20 °C
View Scheme
参考文献
Kozaki, Masatoshi; Okada, Keiji
Organic Letters, 2004 , vol. 6, # 4 p. 485 - 488
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=75°C;
参考文献
KARO BIO AB
Patent: WO2007/3419 A1, 2007 ;
Location in patent: Page/Page column 57; 58 ;
WO 2007/003419 A1
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=75°C;
参考文献
KARO BIO AB
Patent: WO2007/3419 A1, 2007 ;
Location in patent: Page/Page column 58; 59 ;
WO 2007/003419 A1
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=70°C;
参考文献
KARO BIO AB
Patent: WO2007/3419 A1, 2007 ;
Location in patent: Page/Page column 66; 67 ;
WO 2007/003419 A1
