4,6-二氯-1-甲基-1H-吡唑并[3,4-d]嘧啶合成路线

5401-15-01-甲基-1H-吡唑并[3,4-d]嘧啶-4,6(5H,7H)-二酮

参考文献

PROGENICS PHARMACEUTICALS, INC.; HAN, Amy, Qi; WANG, Eric; GAUSS, Carla; XIE, Walter; COBURN, Glen; DEMUYS, Jean-Marc
Patent: WO2010/118367 A2, 2010 ;
Location in patent: Page/Page column 94 ;

60-34-4甲基肼+

50270-27-42,4,6-三氯-5-嘧啶甲醛

98141-42-54,6-二氯-1-甲基-1H-吡唑并[3,4-d]嘧啶

参考文献

US2008/234262 A1, ;

Page/Page column 83-84 ;

5334-41-85-氨基-1-甲基-吡唑-4-甲腈+

503-38-8氯甲酸三氯甲酯

98141-42-54,6-二氯-1-甲基-1H-吡唑并[3,4-d]嘧啶

参考文献

Roecker, Anthony J.; Mercer, Swati P.; Harrell, C. Meacham; Garson, Susan L.; Fox, Steven V.; Gotter, Anthony L.; Prueksaritanont, Thomayant; Cabalu, Tamara D.; Cui, Donghui; Lemaire, Wei; Winrow, Christopher J.; Renger, John J.; Coleman, Paul J.
Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 9 p. 2079 - 2085

98141-42-54,6-二氯-1-甲基-1H-吡唑并[3,4-d]嘧啶+

17356-08-0

30682-70-3

参考文献

Cheng; Robins
Journal of Organic Chemistry, 1958 , vol. 23, p. 852,855
Journal of Organic Chemistry, 1959 , vol. 24, p. 1570

98141-42-54,6-二氯-1-甲基-1H-吡唑并[3,4-d]嘧啶

91843-67-3

参考文献

MERCK SHARP and DOHME CORP.; ALTMAN, Michael, D.; BIENSTOCK, Corey, E.; BUTCHER, John, W.; CHILDERS, Kaleen Konrad; DI FRANCESCO, Maria Emilia; DONOFRIO, Anthony; ELLIS, John Michael; FISCHER, Christian; HAIDLE, Andrew, M.; JEWELL, James, P.; KNOWLES, Sandra Lee; NORTHRUP, Alan, B.; OTTE, Ryan, D.; PETERSON, Scott, L.; SMITH, Graham Frank
Patent: WO2013/52394 A1, 2013 ;

98141-42-54,6-二氯-1-甲基-1H-吡唑并[3,4-d]嘧啶

5444-33-7

参考文献

Cheng; Robins
Journal of Organic Chemistry, 1958 , vol. 23, p. 852,855
Journal of Organic Chemistry, 1959 , vol. 24, p. 1570

98141-42-54,6-二氯-1-甲基-1H-吡唑并[3,4-d]嘧啶

5413-96-74-氯-1,6-二甲基-1H-吡唑并[3,4-d]嘧啶

参考文献

MERCK SHARP and DOHME CORP.; ALTMAN, Michael, D.; BIENSTOCK, Corey, E.; BUTCHER, John, W.; CHILDERS, Kaleen Konrad; DI FRANCESCO, Maria Emilia; DONOFRIO, Anthony; ELLIS, John Michael; FISCHER, Christian; HAIDLE, Andrew, M.; JEWELL, James, P.; KNOWLES, Sandra Lee; NORTHRUP, Alan, B.; OTTE, Ryan, D.; PETERSON, Scott, L.; SMITH, Graham Frank
Patent: WO2013/52394 A1, 2013 ;
Location in patent: Paragraph 00200 ;

98141-42-54,6-二氯-1-甲基-1H-吡唑并[3,4-d]嘧啶

5413-96-74-氯-1,6-二甲基-1H-吡唑并[3,4-d]嘧啶

参考文献

Roecker, Anthony J.; Mercer, Swati P.; Harrell, C. Meacham; Garson, Susan L.; Fox, Steven V.; Gotter, Anthony L.; Prueksaritanont, Thomayant; Cabalu, Tamara D.; Cui, Donghui; Lemaire, Wei; Winrow, Christopher J.; Renger, John J.; Coleman, Paul J.
Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 9 p. 2079 - 2085

98141-42-54,6-二氯-1-甲基-1H-吡唑并[3,4-d]嘧啶+

74-89-5甲胺

5326-77-2

参考文献

Cheng; Robins
Journal of Organic Chemistry, 1958 , vol. 23, p. 852,855
Journal of Organic Chemistry, 1959 , vol. 24, p. 1570

98141-42-54,6-二氯-1-甲基-1H-吡唑并[3,4-d]嘧啶

5334-35-0

参考文献

F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; FENG, Jianwen; HAYNES, Nancy-Ellen; HERMANN, Johannes Cornelius; KIM, Kyungjin; LIU, Jin-Jun; SCOTT, Nathan Robert; YI, Lin; ZAK, Mark; ZHAO, Guiling
Patent: WO2013/182546 A1, 2013 ;
Location in patent: Page/Page column 85 ;